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Database: UniProt
Entry: A0A196SII8_BLAHN
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ID   A0A196SII8_BLAHN        Unreviewed;      1089 AA.
AC   A0A196SII8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   08-MAY-2019, entry version 14.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=AV274_1406 {ECO:0000313|EMBL:OAO16850.1};
OS   Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII).
OC   Eukaryota; Stramenopiles; Blastocystidae; Blastocystis.
OX   NCBI_TaxID=478820 {ECO:0000313|EMBL:OAO16850.1, ECO:0000313|Proteomes:UP000078348};
RN   [1] {ECO:0000313|EMBL:OAO16850.1, ECO:0000313|Proteomes:UP000078348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50177 / NandII {ECO:0000313|Proteomes:UP000078348};
RA   Gentekaki E., Curtis B., Stairs C., Eme L., Herman E., Klimes V.,
RA   Arias M.C., Elias M., Hilliou F., Klute M., Malik S.-B., Pightling A.,
RA   Rachubinski R., Salas D., Schlacht A., Suga H., Archibald J.,
RA   Ball S.G., Clark G., Dacks J., Van Der Giezen M., Tsaousis A.,
RA   Roger A.;
RT   "Nuclear genome of Blastocystis sp. subtype 1 NandII.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAO16850.1}.
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DR   EMBL; LXWW01000056; OAO16850.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000078348; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078348};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078348};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       97    464       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      528    961       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1001   1070       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1089 AA;  123800 MW;  7911AD2216B1BB9C CRC64;
     MSQKREHIES LSPRKEARLD AKSRYAAYKE EGNRFLRDKA IVRKSAKTIS DQSDNIVFEW
     IDVDLYDGLM MKRVDATHVA MDPDSERCPV IRFFGITNDG HSVCANVHNF LPYFFISKHP
     HYNHATDKED FMCYLTNRMK ERKCAGRVLD IEMVKRKNIY LYHENDEEFM KITLQFPVDV
     PPCRDILHLK GSVASEFKNY RAAAQAKALG QAPPPPASFA SNNVHLHDIF EAKLPFVMRF
     MVDHKIVGCN WLELKAGSYR LLPEAERRST CQYECDVLYT DLVSHSTQDE FSHIAPYRIF
     SFDIECCAEE GGFPEPEKDA VITIANVITE QGSTEPLFKS VFTMGSCSSI PGVEVYAFED
     EAELLAAWAR YMVACDPDII TGYNIQNFDI DYLMKRAAAL KVADFPLLGR IKGEHAKSKN
     TVFSSSAYGM HENVETTIAG RLVFDLLQFV RREYKLSSYT LNNVSSEFLG QHKEDVKYNQ
     IKDLFHGDEV TRQRIASYCV KDALLPQQLL DKLNVIINQV EMARVSGVPI NLLLSRGQQI
     KVMSMLSRKS IELGYIIPTL DRAQQDQQYE GATVIEPKKG FYKEPIATLD FASLYPSIMI
     AHNICYSTLV PRGIDIDPAR VEAAPTGERF VRSGEREGVL PIILRELLAA RKVAKKDMAR
     ETDPLKKAVQ NGRQLALKIS ANSVYGFTGA VVGQLPCLAI SKSVTAYGRQ MIDMTQKTVM
     EHYSVKNGYK HDAVIVYGDT DSVMVKFGVE TVEEAMQIGK EAAALVSERF PSPVRLEFEK
     VYCPYLLMNK KRYAGLFWTK PDHWDKLDAK GIETVRRDNC RLVRILVDTC LKKMLIDRSP
     EDAVEYVKNT LSALLQNQID LSLLVITKAL GKKADGKDGK KEGYKTRAAH VELAERMAKR
     DPGSAPKVGD RVPYVIIQKE KNAQAYMKSE DPIYVLDHNL SIDTEWYLNH QLRGPIERIF
     EGVLADSTLK GLFQGDHMNV KKVVTSQNTG IGRFVSKQNT CLKCKCPLKS GAVCQNCKQY
     ESQYYVQTAM QVELQERQYC ELWTTCQRCQ NSLHQEIICG NKDCPIYYQR EKIKKDLETS
     MAKLKRFSE
//
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