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Database: UniProt
Entry: A0A196SKE0_BLAHN
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ID   A0A196SKE0_BLAHN        Unreviewed;       973 AA.
AC   A0A196SKE0;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   08-MAY-2019, entry version 15.
DE   SubName: Full=Phosphoribosylamine-glycine ligase {ECO:0000313|EMBL:OAO16389.1};
GN   ORFNames=AV274_1920 {ECO:0000313|EMBL:OAO16389.1};
OS   Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII).
OC   Eukaryota; Stramenopiles; Blastocystidae; Blastocystis.
OX   NCBI_TaxID=478820 {ECO:0000313|EMBL:OAO16389.1, ECO:0000313|Proteomes:UP000078348};
RN   [1] {ECO:0000313|EMBL:OAO16389.1, ECO:0000313|Proteomes:UP000078348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50177 / NandII {ECO:0000313|Proteomes:UP000078348};
RA   Gentekaki E., Curtis B., Stairs C., Eme L., Herman E., Klimes V.,
RA   Arias M.C., Elias M., Hilliou F., Klute M., Malik S.-B., Pightling A.,
RA   Rachubinski R., Salas D., Schlacht A., Suga H., Archibald J.,
RA   Ball S.G., Clark G., Dacks J., Van Der Giezen M., Tsaousis A.,
RA   Roger A.;
RT   "Nuclear genome of Blastocystis sp. subtype 1 NandII.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAO16389.1}.
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DR   EMBL; LXWW01000085; OAO16389.1; -; Genomic_DNA.
DR   OrthoDB; 105366at2759; -.
DR   Proteomes; UP000078348; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:InterPro.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:InterPro.
DR   GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   CDD; cd08645; FMT_core_GART; 1.
DR   CDD; cd02196; PurM; 1.
DR   Gene3D; 3.30.1330.10; -; 1.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   Gene3D; 3.90.650.10; -; 1.
DR   HAMAP; MF_00741; AIRS; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   HAMAP; MF_01930; PurN; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004607; GART.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   PANTHER; PTHR10520; PTHR10520; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   SUPFAM; SSF55326; SSF55326; 1.
DR   SUPFAM; SSF56042; SSF56042; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   TIGRFAMs; TIGR00878; purM; 1.
DR   TIGRFAMs; TIGR00639; PurN; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078348};
KW   Ligase {ECO:0000313|EMBL:OAO16389.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078348}.
FT   DOMAIN      110    315       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   973 AA;  104486 MW;  658506CE60D643D7 CRC64;
     MSNVLVIGGG GREHTIAWKL AQSEKVKHVF VAPGNGGTAS MEKVSNVAIS EKDHDKIIAF
     CRENAISLVA VGPEVPLVAG LADKLEKESI HCFGPCARAA MIEGSKQFSK DLMKKYGILT
     AEYECFDNYE KALAYVKSVD HPVVIKASGL AAGKGVLLPE RGQEEAALKE VMVDAEFGAA
     GDVVVIEERL EGEEVSLLCF TDGETVVSMP PAQDHKRAND NDEGLNTGGM GAYAPAPCLP
     PYLRRQAEKE VLEKCIQGLK AEGITYRGVL YAGLMLTKKG IEVLEFNCRF GDPETEVILP
     LLKSDLYDVM MACCTGTLKD AEVEWRDASA VTVVAASAGY PLSYKKGFVI EGLEEAAAMP
     NVTVFHAGTK CEEGAIKTSG GRVLTVTAME PTFHAALSTA YKAVEAIHFE GMHYRHDIGG
     RAVKAGVRVG ILGSTRGTDM VAIHEAIEAG RLNAKIACVV SNIKTAGILE KARAWDIPAF
     HVTGKDVSRE AQEAEVIKVL EAYGCDLVIL IGYMRILTPY FFAHFHKRVI NVHPSLLPEY
     AGGMNNNVHE AVLADKRLES GCTVHEVTPE VDAGAILYQK HVPVFSRDTV ETLKARVQQA
     EGEALIHCIE LFAKDELTPV KEDKEVVSYA DAGVDISEGD QLVENIKPFC KATNRPGCNV
     DLGGFGGLFE LGKAGYGDPD TILVACDDGV GTKVKLAFST GIHDTVGIDL VAMSVNDLIV
     QGAEPLFFLD YYATGHLDNK VATPVVKGIC DGCKLARCAL IGGETAEMPS LYAEGEYDLA
     GFAVGAVKRQ DVLPKPTTPG MVVFGLPSSG CHSNGYSLVR RLVDKSGLQY SSPCPWMPEK
     SLGEVLITPT RIYVPAVLAA CKTKKVAGFA HITGGGLLEN IPRVLAPNTS CKINSGSWPV
     LDVFRWLKAV GKCSEHEMLR TFNCGIGMVV IAERDAAEEV RAVLEKEGET VYEIGEIIDT
     PGKNEVIMNG RVF
//
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