ID A0A196SP60_BLAHN Unreviewed; 866 AA.
AC A0A196SP60;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Protein kinase {ECO:0000313|EMBL:OAO17996.1};
DE Flags: Fragment;
GN ORFNames=AV274_0239 {ECO:0000313|EMBL:OAO17996.1};
OS Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII).
OC Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC Blastocystis.
OX NCBI_TaxID=478820 {ECO:0000313|EMBL:OAO17996.1, ECO:0000313|Proteomes:UP000078348};
RN [1] {ECO:0000313|EMBL:OAO17996.1, ECO:0000313|Proteomes:UP000078348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50177 / NandII {ECO:0000313|Proteomes:UP000078348};
RA Gentekaki E., Curtis B., Stairs C., Eme L., Herman E., Klimes V.,
RA Arias M.C., Elias M., Hilliou F., Klute M., Malik S.-B., Pightling A.,
RA Rachubinski R., Salas D., Schlacht A., Suga H., Archibald J., Ball S.G.,
RA Clark G., Dacks J., Van Der Giezen M., Tsaousis A., Roger A.;
RT "Nuclear genome of Blastocystis sp. subtype 1 NandII.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAO17996.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LXWW01000011; OAO17996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A196SP60; -.
DR STRING; 478820.A0A196SP60; -.
DR OrthoDB; 5483964at2759; -.
DR Proteomes; UP000078348; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04371; DEP; 1.
DR CDD; cd05123; STKc_AGC; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.30.1470.10; Photosystem I PsaD, reaction center subunit II; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR InterPro; IPR045270; STKc_AGC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF390; SERINE_THREONINE-PROTEIN KINASE SGK-1; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:OAO17996.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000078348};
KW Transferase {ECO:0000313|EMBL:OAO17996.1}.
FT DOMAIN 213..298
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 471..603
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT DOMAIN 654..866
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 606..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 683
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 866
FT /evidence="ECO:0000313|EMBL:OAO17996.1"
SQ SEQUENCE 866 AA; 98698 MW; 64E7AD27BBC85DD3 CRC64;
MPMDNNYILL QEDTNANYEP TEEEVRAEAK YLGIAPEDSD LMWIAKEALR APLPRHWSPY
QHRETGSIVY YNKKTGAISE NHPMDEYFRG LYHKLKDDPT SSRIPKPSTV SSIITTSADL
EALVKAVNQA AVEVNLYNEW LEETVKSLKQ TVDKIAFLEN RMKGVMKPSS FVTKMMVNEG
KSDTSSKQAS ASHAGDTTLP LLPARIMQML NSMRNTLEVK DREYGSKMYS TCFTAACAID
WLLINGFVDS RNEGVNLCQE LLDSQQIVAL TSVGNVFQVV FFVLSHTQDT DDLFAFKADQ
QISRPLTSSE TATWASLLEV AINTHNIKQL ASLLTELRQQ TFYHLLYREQ GEWKERKRID
RRGNYVLSCV LSHKQILVER PTTQQGNYNI LRSTREISGD AEEVYRDLLI GDMPGQQISG
RARWEKRLSR EEVLCTIDGV SNEERIPFVH RLFKNRKADG AVNDGASVIL KEWKKMGGMA
RSAHTYNDIP QGIRVVHRYM KSGSGFATCR DLVLLQDHFR TEEGCYVIYE VSVNGDLPSR
TAGKRASYVR AEVLLSAYLL IPAGRDKCRL SMFCQYNDYQ SLLLMLLKTR PLITCDVTGF
RHVPLGDHPM SADTPSSNSE TVENEPMEAE HEPSVEEVVA PPVATHGEVH LEDFKVLALL
GRGGYGKVLH VYCAKTGQYF AMKVLKKDEI VRRRQVSRTK VERLILERAN FPFITRLYYA
YQTPYRLYMV IDYMQCGDLF THLSRFGVFT EDRARLYIAE IVLALEHLHN MGIIYRDLKP
ENVLLGADGH VKLTDFGLSR YYSLCGELKR PIGELRSYSY CGTEQYMAPE MLLRRPHTEA
IDWWSLGILL CECLTGCHPF QGHSHH
//
