ID A0A197JWQ6_9FUNG Unreviewed; 621 AA.
AC A0A197JWQ6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Dbl homology domain-containing protein {ECO:0000313|EMBL:OAQ28714.1};
GN ORFNames=K457DRAFT_544577 {ECO:0000313|EMBL:OAQ28714.1};
OS Linnemannia elongata AG-77.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mortierellomycotina;
OC Mortierellomycetes; Mortierellales; Mortierellaceae; Linnemannia.
OX NCBI_TaxID=1314771 {ECO:0000313|EMBL:OAQ28714.1, ECO:0000313|Proteomes:UP000078512};
RN [1] {ECO:0000313|EMBL:OAQ28714.1, ECO:0000313|Proteomes:UP000078512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG-77 {ECO:0000313|EMBL:OAQ28714.1,
RC ECO:0000313|Proteomes:UP000078512};
RG DOE Joint Genome Institute;
RA Uehling J., Gryganskyi A., Hameed K., Tschaplinski T., Misztal P., Wu S.,
RA Desiro A., Vande Pol N., Du Z.-Y., Zienkiewicz A., Zienkiewicz K.,
RA Morin E., Tisserant E., Splivallo R., Hainaut M., Henrissat B., Ohm R.,
RA Kuo A., Yan J., Lipzen A., Nolan M., Labutti K., Barry K., Goldstein A.,
RA Labbe J., Schadt C., Tuskan G., Grigoriev I., Martin F., Vilgalys R.,
RA Bonito G.;
RT "Genome sequencing reveals origins of a unique bacterial endosymbiosis in
RT the earliest lineages of terrestrial Fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KV442046; OAQ28714.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A197JWQ6; -.
DR STRING; 1314771.A0A197JWQ6; -.
DR OrthoDB; 2734911at2759; -.
DR Proteomes; UP000078512; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000078512}.
FT DOMAIN 93..278
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 317..475
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 482..603
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 68512 MW; 700C48350219125F CRC64;
MLLRKQSEGS LSSHLSVPTT HNPAMRQRSG SHSEAVSRSY THPRFTSESQ VSQTPSRGMS
IDRSPSPLLL NSPSWSASVG MGMSHSLSEK ERKRQEAIHE LITTERVYLG YLYLVRDEFQ
RPLLDQGLVS PFESQSLFME WSNLLDLSQS IVDELTQRQE SEQGIVLAVG DVINSLIVER
AGCFMKYCAN HREAANLLAR RMTESRLLLE FMTAAKSKPS CRGMDISSFL LQPLQRITRY
PLLIKKILEY TDEDHIDHLL LSEALVSAES FLDRINESIR SGEDKQKLSE IQRKLPAGDL
SEGLVLTSET KFLGPRRVLQ EGSLRKAKSG RKLYAYLCND LLLLFVPGRA AGALAKSASY
TSLSLSASSP SLSSSPSAAA SEGGQNGNHG WTLYHAPIPL ERIKVKPDAN DDTKFTIVVA
SPVPPSSGAQ FSQVPLHLQS QQTSQGGPLQ SMIHVKAGSS RERKAWLGAV QKAIEVLAKA
PRDYGMRTSI RPSLAETIGT MTIRVNEAVI SSREFAKSKS FVCTISLGDQ LFTTRPSSTE
HPFSGAFSIL WRESTIFAIT DMSHVLDVKL MSTCPFSPDV FMGSAQVPFH TVIPYGERGT
EVLTSVGKDT QIKFHMSYKA L
//
