ID A0A197K5Q4_9FUNG Unreviewed; 420 AA.
AC A0A197K5Q4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Karyogamy protein 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=K457DRAFT_122712 {ECO:0000313|EMBL:OAQ32987.1};
OS Linnemannia elongata AG-77.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mortierellomycotina;
OC Mortierellomycetes; Mortierellales; Mortierellaceae; Linnemannia.
OX NCBI_TaxID=1314771 {ECO:0000313|EMBL:OAQ32987.1, ECO:0000313|Proteomes:UP000078512};
RN [1] {ECO:0000313|EMBL:OAQ32987.1, ECO:0000313|Proteomes:UP000078512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG-77 {ECO:0000313|EMBL:OAQ32987.1,
RC ECO:0000313|Proteomes:UP000078512};
RG DOE Joint Genome Institute;
RA Uehling J., Gryganskyi A., Hameed K., Tschaplinski T., Misztal P., Wu S.,
RA Desiro A., Vande Pol N., Du Z.-Y., Zienkiewicz A., Zienkiewicz K.,
RA Morin E., Tisserant E., Splivallo R., Hainaut M., Henrissat B., Ohm R.,
RA Kuo A., Yan J., Lipzen A., Nolan M., Labutti K., Barry K., Goldstein A.,
RA Labbe J., Schadt C., Tuskan G., Grigoriev I., Martin F., Vilgalys R.,
RA Bonito G.;
RT "Genome sequencing reveals origins of a unique bacterial endosymbiosis in
RT the earliest lineages of terrestrial Fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC {ECO:0000256|ARBA:ARBA00003389, ECO:0000256|RuleBase:RU368082}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368082}. Nucleus membrane
CC {ECO:0000256|RuleBase:RU368082}.
CC -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000256|ARBA:ARBA00010473,
CC ECO:0000256|RuleBase:RU368082}.
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DR EMBL; KV442022; OAQ32987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A197K5Q4; -.
DR OrthoDB; 1365785at2759; -.
DR Proteomes; UP000078512; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:UniProtKB-UniRule.
DR InterPro; IPR007292; Nuclear_fusion_Kar5.
DR PANTHER; PTHR28012; NUCLEAR FUSION PROTEIN KAR5; 1.
DR PANTHER; PTHR28012:SF1; NUCLEAR FUSION PROTEIN KAR5; 1.
DR Pfam; PF04163; Tht1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368082};
KW Karyogamy {ECO:0000256|ARBA:ARBA00022459, ECO:0000256|RuleBase:RU368082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|RuleBase:RU368082};
KW Reference proteome {ECO:0000313|Proteomes:UP000078512};
KW Signal {ECO:0000256|RuleBase:RU368082, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..420
FT /note="Karyogamy protein 5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008276601"
FT REGION 349..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 48192 MW; 89802C7AAEDFA049 CRC64;
MQTPPFRRIV CLLATLLLLA TLPTLSHAFW SQQRPQQQHV KSNVHDNNDQ TSHDSFARDD
FVSVEEMYTL QHATGTPTGT CHITEQRNAL KAYDSKPDCF KDAARALQQG CKSIDIDEDE
KTRYAIRLTT CEIATANMPI PQECHSLASA ESDPDKQPTA NDISRCVQSL GRVPQLWTSY
SGYFREVKVM CLAVRYSLEH EQQRVLKETN RLETEQLKQL SALHSTITAD VNSMLTLASV
SQSMRHWNDS LERGISRAQE IDRLNQDSIL LLWRFCAHLL DCCRVLRKAQ RENAVEQEQE
REYEYGVDDQ CAERYLDTDS SEEEEEDLEM EEHVWQQYDD DTFEQRATAR YNNPTSPSTP
TPSTRKPKRQ YQYHSTSIGH IPLTKPSMDM EMDMWERVAA SWDLSLGTCV SSSSTSGDIY
//
