ID A0A197SQ25_9ACTN Unreviewed; 160 AA.
AC A0A197SQ25;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase {ECO:0000256|ARBA:ARBA00012257};
DE EC=4.1.1.97 {ECO:0000256|ARBA:ARBA00012257};
GN ORFNames=A8W25_18825 {ECO:0000313|EMBL:OAR24982.1};
OS Streptomyces sp. ERV7.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1322334 {ECO:0000313|EMBL:OAR24982.1, ECO:0000313|Proteomes:UP000078470};
RN [1] {ECO:0000313|EMBL:OAR24982.1, ECO:0000313|Proteomes:UP000078470}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ERV7 {ECO:0000313|EMBL:OAR24982.1,
RC ECO:0000313|Proteomes:UP000078470};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-
CC carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:58639; EC=4.1.1.97;
CC Evidence={ECO:0000256|ARBA:ARBA00001163};
CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
CC urate: step 3/3. {ECO:0000256|ARBA:ARBA00004754}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAR24982.1}.
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DR EMBL; LYOY01000040; OAR24982.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A197SQ25; -.
DR STRING; 1322334.A8W25_18825; -.
DR Proteomes; UP000078470; Unassembled WGS sequence.
DR GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 2.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR PANTHER; PTHR43466; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR43466:SF1; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR Pfam; PF09349; OHCU_decarbox; 2.
DR SUPFAM; SSF158694; UraD-Like; 1.
PE 4: Predicted;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000078470}.
FT DOMAIN 5..62
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
FT DOMAIN 66..143
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
SQ SEQUENCE 160 AA; 17490 MW; 09E1728FC3929417 CRC64;
MTRFNRAPGP AAEAVLLACC ASRRWALRMA AHRPYPDLDA LLAAADEASY DLSPDDLTEA
LAEERSPGLD ATAPQSAHTA LRAAHAAYES RFGHAFVICL AGRRPTEHLN EMLGGIRVRM
TNEQDEERAI AADELRRLAR ARLTHLMTNH PEPDTAGAPR
//
