ID A0A197SWT3_9ACTN Unreviewed; 525 AA.
AC A0A197SWT3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Choline oxidase {ECO:0000313|EMBL:OAR27331.1};
GN ORFNames=A8W25_03510 {ECO:0000313|EMBL:OAR27331.1};
OS Streptomyces sp. ERV7.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1322334 {ECO:0000313|EMBL:OAR27331.1, ECO:0000313|Proteomes:UP000078470};
RN [1] {ECO:0000313|EMBL:OAR27331.1, ECO:0000313|Proteomes:UP000078470}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ERV7 {ECO:0000313|EMBL:OAR27331.1,
RC ECO:0000313|Proteomes:UP000078470};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAR27331.1}.
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DR EMBL; LYOY01000001; OAR27331.1; -; Genomic_DNA.
DR RefSeq; WP_067155535.1; NZ_LYOY01000001.1.
DR AlphaFoldDB; A0A197SWT3; -.
DR STRING; 1322334.A8W25_03510; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000078470; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11552:SF152; OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000078470}.
FT DOMAIN 266..280
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 91
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 494
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 525 AA; 57557 MW; AFB44CDF9213CB0A CRC64;
MNEANTGPAA DEFDYVVVGG GTAGNVVAAR LSEDPSVTVC VLEAGPSDVG DDNVLRLERW
MGLLESGYDW DYPVEPQERG NSMMRHARAK VLGGCSSHNS CIAFWAPAED LDGWAAEGCT
GWGAEDVFPL YKRLENNDAP GEHHGRSGPV KLRTIKGEDP CGSALLDACA QTGIPTTPFN
TGRTVIRGAN WFQINSDENN IRQSSSVAYL HPIIGKRPNL TVRTGIRAKR LVIGEDRRCT
GVEYLDPDLI HSRTVSARRE VVVSCGSIDT PKLLMLSGIG PADHLREVGV EALVHSPGVG
ENLQDHPEGV IMWDAKRPMP TRSNQWWEIG IFADTEPGLD RPDLMFHYGS VPFDMNTTRH
GYPTSENAFC LTPNVTHAKS RGTVRLRTRD YRDKPMVDPR YFTHEHDVRV MTYGLKLARE
IAAQPALADW AGAELAPGPD VRTDDELFEY IRTTHNTVYH PACTVKMGAD DDAMAPLDAR
LRVKGIRGLR VADGSVMPEL VTVNPCITTM MIGEKCADMI KADAV
//
