ID   A0A199VJ95_ANACO        Unreviewed;      3960 AA.
AC   A0A199VJ95;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Sacsin {ECO:0000313|EMBL:OAY76820.1};
GN   ORFNames=ACMD2_08207 {ECO:0000313|EMBL:OAY76820.1};
OS   Ananas comosus (Pineapple) (Ananas ananas).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Bromeliaceae;
OC   Bromelioideae; Ananas.
OX   NCBI_TaxID=4615 {ECO:0000313|EMBL:OAY76820.1, ECO:0000313|Proteomes:UP000092600};
RN   [1] {ECO:0000313|EMBL:OAY76820.1, ECO:0000313|Proteomes:UP000092600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MD2 {ECO:0000313|Proteomes:UP000092600};
RC   TISSUE=Leaf {ECO:0000313|EMBL:OAY76820.1};
RX   PubMed=27374615; DOI=10.1093/dnares/dsw026;
RA   Redwan R.M., Saidin A., Kumar S.V.;
RT   "The draft genome of MD-2 pineapple using hybrid error correction of long
RT   reads.";
RL   DNA Res. 0:0-0(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAY76820.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LSRQ01001710; OAY76820.1; -; Genomic_DNA.
DR   STRING; 4615.A0A199VJ95; -.
DR   Proteomes; UP000092600; Unassembled WGS sequence.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR15600; SACSIN; 1.
DR   PANTHER; PTHR15600:SF42; SACSIN; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 2.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092600};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN          3914..3948
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          2934..2955
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3960 AA;  444231 MW;  6FDB41CC886C2308 CRC64;
     MDRSAASGAD AAAETALLED FGQRVDLTRR IREVLVNYPE GTTVLKELIQ NADDAGATRV
     CLCLDRRKHG AESLLSPKLA QWQGPALVAY NDAGFTDDDF VSISRIGDSK KQSQAWKTGR
     FGNILMIAWI MEDKVGYSTV IRLGWNAKDH DLHLLPWASV AACISDGEPE GAVLKEGHAF
     CFLPLPVKTG LAVQVNGYFE VSSNRRNICD LDDVVVGRYL NGLPLLPLAN NQFGVFSEVS
     QGNFYFICNE LEYKLLSAVP DRIIDPNIPS KLLSKLSDVA HFSKANIALV DGQIFLQFFP
     RLFPAEWKYK NQVDWNPELG STFPTTAWFE LFWKYLRERS YDLELFSDWP LLPSTSGHLH
     RPSKLSKLIN AELLSSTIEE LLAKIGCKIL STQYGVEHQQ LSLYVYDGDV AGVIHSIFEA
     VSSSGNPLHS LFQYIAPDEK NELRQFLLDP KWYLRGSLSD DDMKNCKKLP IYRVYAEGDV
     NICYFSDLDT FKLYLPPLGM PEYLLDGDFI FCSSQSEEEI LMRYLKIERM KRSSFYKKSV
     LNRVGELQPE IRDAVMLTVL RELPQLCLED PLFKESLRVL NFVPTITGSL RSPQSLYDPR
     VEELYVLLQE SDCFPCGLFQ ESDVLDMLLS LGLRTSVHLD TVIQSARQIE MLMHKDQSKA
     NLRGKVLLAY LEVHANKWVS NRPRDGQRKA NVMFAKVTMA LRTRDIPLEA DLEKFWSNLR
     MICWCPVLVS PPHPALPWPA VSSKVAPPKQ VRLHSDMWLV SASSRILDGD CSSSALSYSL
     GWSFPPAGSV IAAQLLELGK NNEIVTDQVL RQELALAMPK IYSLLTNLIG SDEMDIVKAV
     LEGCRWIWVG DGFATAEEVV LTGHLHLAPY IRVIPVDLAV FRELFLELSI KEYLKPADYA
     NILSRIAMRK GSAPLDGEEL RTSVLIVQHL SDFQFEDSSA QIYLPDALSR LCRSTDLVFN
     DAPWLLDFGE STYTKKDVYN FVHGHISNDV AEKLGVRSLR RLLLAESSDS MNLSLSGVAE
     AFGQHEALTT RLKHIVEMYA DGPGILFELV QNAEDAHASE VIFLLDKTQY GTSSILSPEM
     AEWQGPALYC FNDSVFSSQD LYAISRIGQD SKLEKPFAIG RFGLGFNCVY HFTDIPGFVS
     GENIVIFDPH ACYLPGISPS HPGLRIRFVG RRILEQFPDQ FSPFLQFGCD LQQAFPGTLF
     RFPLRNEAAA NRSQIKKEKY APEDVELLFS SFSEVVSEAL LFLRNVQKVT LYVKEGSGHE
     MQLMHCASRR HAGVITKESH AHQAMLDFIR GSRQNGMDRA QFLNRLNKTL DSELPWNCQK
     VAIVEETPMA SMLHSWIISD CIGGGQAKRR SIVMGNKSHN FVPWACVAAY LHSAYIKDVK
     ELGETFSSSG EIVDTDASLK YQAPRKKFEG RAFCFLPLPI TTSLPAHVNA YFELSSNRRD
     IWFGNDMAGG GKARSEWNTC LLEDVAAPAY AHLLSVMAEE IGPSDLFFSF WPTTVGAEPW
     ASMVRKLYMC IADLGLPVLY TKARGGQWIS TRQAIFPDFS FSMAAELSEV LAQAGLPIVS
     VSKLIVDKFM ETCPSLHFLN PSLLRNLLIR RKRGFKSKEA VICTLEYCLS DIKESGFSDK
     LHGLPLLPLA NGSLTVINKC GEGERIFFTS QMEYELLKDS VPHLLIDCSI PDGILKKLSN
     IADSAQSNIQ LFTCSCLVDL LPRILPPEWQ QAKQVSWTPG QQGHPSLEWM KLLWSYLQDS
     CKDLSILSKW PILPVGNDCL LQLAENSNVI RDDGWSENMY SLLQKLGVFF LRSDLPIDHP
     QLKHFVQDST APGVLNAVWS VASQLQDIKE LFANASVAEM HELRSFIFQS KWFSEEDASR
     KAALSEIPFV LAANGSWLHP SRLYDPRVPE LRSLLHKELF FPSEKFIDAE ILESLTSMGL
     KRSLSFSCLL DSAKSVSMMH ASGDRDAFIY GQRLLVYLDA LSFKLSTHGR QSNDGAASLI
     ISNYAMVYDD DLQAENNEDD NGNWDADVLS FLSHFEHDLT EDEFWLEIKT ICWCPAYVAP
     LVKGLPWLVS EDKIAPPIIT RPKSQMWLVS SRMRILDGNC KSMYLQQKLD WLDPADIRVY
     SAQLIELSKS YNNLKTQPEQ DCPIDVVLEK EIPSMYSKLQ EFIGTNNFKF LKEDLDGVPW
     VYVGDNFVPP KALAFDSPVK YHPYLYVVPS ELSEFRALLS ALGVRMTFDA SDYLNVLQCL
     QRDVKGELLS ADQLTFVHCV LEAFVDSYAG KQVPDLMLKS LLIPDSLGVL MPALNLVYND
     APWMKDSSPG SKHFVHSSIS DDLAKRLGVQ SLGGLTLVED ELMRDLPCMN YPKICELLAL
     YGESDLVLFD LLELADFCNA KKVHLIYDKR EHPRQSLLQQ NLGDFQGSSL TVVFEGVTLS
     QEEVCNLQLP PPWKVQGGVL NYGLGLISSY FVCDVLTVLS GGYFYIFDPL GLTLGAPSSG
     VPSARLFSLS GTNLVERFRD QFYPMLVTKE ISLSSSNSTV IRMPLSSKCL KELETVSKRV
     KQIFDRFMQH SSSTLLFLKS ILQVSLSTWE EGNSQPSLNY SVFIDPTFAI LRNPFSEKKW
     RKFQISRLFT GSNAGIKMHA IDVSVIESGS SYIDKWLVVL CLGSGQTRNM ALDRRYLAYN
     LTPVAGVAAH VSRNGSPLSV QSSSCILSPL PLSGSVSMPV TALGYFLVSH NGGRYIFTHD
     ETTSPELHID STKQLVEAWN KELMLCIRDS YVELVLEFQK LRKDPGASAV ESKSAHSLSS
     VLQAYGDRIY SFWPRSRQQP TLSDNLCLSK ATEADWESLI EQVIRPFYKR LVDLPVWQLY
     RGNLVRVDEG MFLSQPGSDG VNLPSASVCS FIKEHYPVFS VPWELVGEIR AAGIKVREIQ
     PKMVRDLLRA SSSVILRSID TYIDVLDYCF SDIHPTQPAN LRPVENMSKS VTEMQPSSSS
     SMLHSHHTVS QSTGTPGGDA LEIMTYFGKA LYDFGRGVVE DISKAGGPIA HATSSAGSSN
     LHADRLLSSL IAEFKGVPFP TATKCLIRLG TTELWIGNKE QQLVMHPLAD KFIHHQCLEK
     PILAAVLSYP AIHRPLMLRH FSPHLLSGHL RVLFHEHWVK LVETSRAPWI SWGNSTESSS
     YGPTPEWIRS FWKIYESLQG DLSLLSDWPL VPAYLNGPVL CRVKVRHLVF VPPVTDLTLE
     NSGEFGLASN NISETELEKL HHVAFNFTNS RHPWLFPLLN QFNIPLYDIS YPELDVLCKF
     VPARSQTIGH AIVFKLLAAK RAGYLSVPVQ LSDEDRDRLF SLFEMDFNAP TQHVYQREEL
     NVLRELPIYK TVLGTYTSLY GSDHWLVSPT AFFHPNDERC LSSSAEASSF YHALGVEQLS
     DQELLVRFAL PFFENKTPQE QDDILLYLYT NWNNLQLNSA VLTILKETNF IKNANELSTE
     LFKPKDLLDP YDSLLTSVFS GEKSKFPGER FVTDGWLRIL KKAGLRTSSE ADMIIECAKK
     VEAMGIDAMT CVEEPDEFEG DFSSSRNEIS FEIWTLGESI VNSIFSNFAT LFDSAFCEKI
     GKIAFVPAEK GFPSIGGKKG GKRFLSSYRD AILLKDWPLA WSSAPILTKQ SVVPPEYSWA
     AFRLRSPPAF STVLKHLQIV GRDNGEDTLA HWPTSSGMIT VENAFLEILQ YLEKTWGTLS
     SSDKTELEKL AFVPVANGTR LVSVKSLFAR LTINMSPFAF ELPSPYLPFI NILRELEMQE
     NLTVSYARDF LLSIQKACGY QRLNPNELRA VMEILNFICC SGTTQAITDE SDIIADTIIP
     DDGCRLVSAR SCVYIDPYGS QILSFIDTSA LRFAHPELPE SIRTFLGIKK LSDIIVENDK
     IQYGKVSATE VVQAVHDMLS AAGVNLDAEK QSLLQTTLSL QEKLKESQVA LLVEQEKAEA
     AVKEADGAKA AWLCRVCLTN EVNITIISCG HVLCNRCSAS VSRCPFCRTQ VSRIMKIFRP
//