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Database: UniProt
Entry: A0A199XNM4_9FLAO
LinkDB: A0A199XNM4_9FLAO
Original site: A0A199XNM4_9FLAO 
ID   A0A199XNM4_9FLAO        Unreviewed;       424 AA.
AC   A0A199XNM4;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   16-JAN-2019, entry version 13.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138,
GN   ECO:0000313|EMBL:OAZ03338.1};
GN   ORFNames=FLB_21250 {ECO:0000313|EMBL:OAZ03338.1};
OS   Flavobacterium succinicans.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=29536 {ECO:0000313|EMBL:OAZ03338.1, ECO:0000313|Proteomes:UP000093807};
RN   [1] {ECO:0000313|EMBL:OAZ03338.1, ECO:0000313|Proteomes:UP000093807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DD5b {ECO:0000313|EMBL:OAZ03338.1,
RC   ECO:0000313|Proteomes:UP000093807};
RA   Poehlein A., Daniel R., Simeonova D.D.;
RT   "Draft genome sequence of Flavobacterium succinicans strain DD5b.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAZ03338.1}.
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DR   EMBL; JMTM01000060; OAZ03338.1; -; Genomic_DNA.
DR   RefSeq; WP_064715920.1; NZ_JMTM01000060.1.
DR   EnsemblBacteria; OAZ03338; OAZ03338; FLB_21250.
DR   PATRIC; fig|29536.5.peg.2222; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000093807; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000093807};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:OAZ03338.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000093807}.
FT   DOMAIN      111    319       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   424 AA;  46018 MW;  CBA556133360AB5C CRC64;
     MNILLLGSGG REHAFAWKMT QSPLCDTLFV APGNAGTATI ATNLDFSATD FEAIKAVVIK
     ENIEMVVVGP EDPLVKGVYD FFLNDADLKH IPVIGPSKLG AQLEGSKEFA KEFMMKHQVP
     TAAYDSFTAE TVEKGCEFLA TLQPPYVLKA DGLAAGKGVL IIQDLAEAQT ELRNMLVGQK
     FGAASSKVVI EEFLDGIELS CFVLTDGKSY KILPTAKDYK RIGEGDTGLN TGGMGAVSPV
     PYVDAVLMEK IETRIVQPTI AGLQKDGIPY KGFVFIGLIN VNNEPIVIEY NVRMGDPETE
     VVIPRLKSDL VELFLAVANE KLADFNLEVD ERSATTVMLV SGGYPEDFEK GKEISGLENV
     ENAIVFHAGT KLDNGTVVTN GGRVMAITSY GATFQEALQQ SYDNVSKIQF EKMNYRKDIG
     FDLI
//
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