ID A0A1A0H4Z3_9ASCO Unreviewed; 2564 AA.
AC A0A1A0H4Z3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=METBIDRAFT_33704 {ECO:0000313|EMBL:OBA19106.1};
OS Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowia.
OX NCBI_TaxID=869754 {ECO:0000313|EMBL:OBA19106.1, ECO:0000313|Proteomes:UP000092555};
RN [1] {ECO:0000313|EMBL:OBA19106.1, ECO:0000313|Proteomes:UP000092555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-4993 {ECO:0000313|EMBL:OBA19106.1,
RC ECO:0000313|Proteomes:UP000092555};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., LaButti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA19106.1}.
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DR EMBL; LXTC01000008; OBA19106.1; -; Genomic_DNA.
DR RefSeq; XP_018709641.1; XM_018856385.1.
DR STRING; 869754.A0A1A0H4Z3; -.
DR GeneID; 30029361; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000092555; Unassembled WGS sequence.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092555}.
FT DOMAIN 1217..1401
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 2564 AA; 292652 MW; DD3AF204EA1F81FB CRC64;
MGSSFINALV SRLDAVLPNR MGHSLAEVEL DSQFIITTNL ILKNCKPNEF NGHQDFFSDI
LKALLSILEK LNIDPQTQKL IDRSTNVLSS TVILTRLLRI IAITKWDPEG NYSQKEDLSM
DVGINFDIES NIAHDIFDLY AHKEPPAVNI DTGHVLGVLF KILSPEINIQ GLSDICKFKP
VPRDVAYSVS PQLGLLAQEL RSQILEIDSN ILILIRYIAA SNPPDYANFV KQRLFSYVNR
GENIPLAALQ RYACLLMFVY CTPNNTSFYL KLVYSAIPYI RSMTWKQLFL HYESINLRIQ
CINKPGFYSN VIYAGSSAEQ ECKIIFDYIS TAIENESNTN TSLLSWYVVL CPSGFDELLL
KSGKLKQVFN KRVKFLHSIL KDSHAGADLD CFESLISIFL WASLLPENEG AVRKFSNRYL
DDTFQNFSKM RLKCVTDSLL ARFRSLHQKL FTAAIAINPD KYISIFIGEF QEKHELQALV
FYDKSKTIDS HDLLEVIMAL SCHSRYRDTV NHLMRQINAT LSNIMHCCAQ ILCQKNAPMS
KTRSLCSSSD VDNIDQDDQE TNPNFWTRPY GSQVPEDQVF MIQNILRLTL DIYTKSPLFF
MQFQFKNSGG TRDEKAHEML KFSDAVFVPL NVAIHSQSTT SRSMFKSACK LSMRLLQVGN
EMDSTDEVHC ISTMISHNVI YSTCEVIGSL SYPAFKEYYI SLKSFLLERI ESPLRAQKND
FYQSKWTHIG CERVCTSLDK LLMLCLCTHD IQFFSLLKLS IKAHSFETCA TRSGFNCFQN
SLAESFCDVM GDDIVFTGFV SLHKKFKSIL ADFKPTRGLY EAWLMIYNRW VEMVDDKTGA
TDDNFTFKHY TEFLATTSGC FLGSMFEESG IGPQELATTV ISSFYDRAVA LLNCEELFIR
VVIREALSTE THSEVYQLIY DKIMNSVRVY KDVSSVSAES VLFFEEAVSI FTSILNIKSE
GAFILAALLP EVIEIFFEYV DIVPNLIDQI KLKLRLCKLT YVMSALRDNF GISGAYKLRN
KFAKIAADWL DSAASYSTDL SNDSTTIASS NGRASDVEFL QIELAAECAK SFSLQLQNLV
LTVPDGTKES NFEQAKILVF SNFFSIFYKI FQKFNGNDPS PLVIKSKFKI QTITEHVLKA
ISNMLRANVG IGLEFAIPLG YHENNKIRSI FLDIFATTLS AGKLKLGEEE FSDSTVYRMS
EIIEVYGAAA RVASPAEHNL LATSLNGLFG YTKGLDKLFL ILLEVEMQSV NRASDIFRGN
STLTRLMSIF AKEYGAPYLS VVLRPFVEEM VQHNVIFEVE RDGKKEDVDL FFKYLRKLVK
SVVNSIPWVP EAFKFICFEI HRCVGKKFDE SSLIAVGSFL FLRFFCPAIV CPESFFDITS
VDIRVKRSLM QIVKAIQYMA NGSILNLKWA SLATRSAEMN DLNAEIFAFM EKIAAERSNE
NYVFHVTLLK PLTCLRYVHK FFYAYFVEIR HNFLVGNQSS DEKCLQQNIL AWRKLDKIMS
ELGNPKPAIS LQGTKSYKSI DAQSNIGNSQ FTEFMAKMSA KNIETSIETP IVKNFVFHDG
TPVVVVTFRY IKEISYDVST MVYLLLETVS QIWENQFYCV IDLTQFYFME IFGKDIANLL
KTYAPRVFFR NCKRTYYYNL PRPSYLAIID SWTDFRPQNN VERSISFYSE QDSSEMIESL
CLSEATMAIP QDVKFVCKSC KLYDDKMSMF TNVTLRLGRL WLLICFERMN LDRDYSPTKS
IAPVEVLRLT DLIKCEISNK SGENNEFTLY LNKFNYQVTL VTPQREEVLR FLYFAMLRSS
KKSKSSRSAA QKSELEQSQR FSALATLLFH GLLQSNDEVR VAASKLLKSF SSYYNITFDS
SSRYFSKASF PVDMTDFVVS YSSSLADHFP QYSHEFLRSF FANFDKFTAS SKISGVMYIS
PWVVNLHEHI SKEIDGVEKM SFIVRQLCKI TTKNPLILSF MKELIWKKIF RDMRMTTILV
DELVAIAMEI ASESDDWNII ISVFHPSVEL CGELVSRLHN CIYKTKKGDS AIVIQSKISE
ISILIKICSS LFFDSFVYGS LYLLDVFLFC TLFIDRSDLD FGHDLQSLVL STIQSFSCKP
LLGDEQVDLI NETVEYFSSQ RAKMLFGLTT KERGAHIDFS QNYERALSFE HLCDYLNNFM
SKIGSADDKK YWISRWSSLS KDIAFSDSFF QMRAYTIVCT LARSGISDSV GGRIMEVLTG
QLFDDPASFF EGSVCFLRLM QGLVSDSVYL PLLVWVIAGA LLLEFPLNYQ AMISSLGKSF
EKMIFDEAFT CKVFAIRSNL EPLISLFEER VDIKIRRENY EFVFLFLISK GLIVSQVRHT
SINTIRRSLL AKGQRQGGHI LKAKSSDDFV LAYLLVYYLS VPDSTFQTLL SELGLEGVPL
TQLGRDKIPD ALLDGICSLC ESLHLGLVLA AHIFIGECEQ IFKFKFIALY AMILERLRDS
ALMIYHIIQA KLEESFINAA SNSLTNDISV ILMRIVRDRS YNPKIWQEKI AVSLRKIEVF
NVDTIHQFEL LNGATESVQR MTIVRQMFYR NLCSVTDGLK LEKF
//
