ID A0A1A0H5B3_9ASCO Unreviewed; 686 AA.
AC A0A1A0H5B3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN ORFNames=METBIDRAFT_46747 {ECO:0000313|EMBL:OBA19140.1};
OS Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowia.
OX NCBI_TaxID=869754 {ECO:0000313|EMBL:OBA19140.1, ECO:0000313|Proteomes:UP000092555};
RN [1] {ECO:0000313|EMBL:OBA19140.1, ECO:0000313|Proteomes:UP000092555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-4993 {ECO:0000313|EMBL:OBA19140.1,
RC ECO:0000313|Proteomes:UP000092555};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., LaButti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC clathrin to receptors in coated vesicles. Clathrin-associated protein
CC complexes are believed to interact with the cytoplasmic tails of
CC membrane proteins, leading to their selection and concentration.
CC {ECO:0000256|PIRNR:PIRNR002291}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA19140.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LXTC01000007; OBA19140.1; -; Genomic_DNA.
DR RefSeq; XP_018709672.1; XM_018858071.1.
DR AlphaFoldDB; A0A1A0H5B3; -.
DR STRING; 869754.A0A1A0H5B3; -.
DR GeneID; 30031047; -.
DR OrthoDB; 648032at2759; -.
DR Proteomes; UP000092555; Unassembled WGS sequence.
DR GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF13; AP-2 COMPLEX SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|PIRNR:PIRNR002291};
KW Reference proteome {ECO:0000313|Proteomes:UP000092555};
KW Transport {ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 15..532
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT REGION 621..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 77191 MW; A93610895A2F9E62 CRC64;
MDAKFFGKSK ASELRAELEQ ARKKLKPQQR VRAVLKKVVA NIILNRPELA LLMPDIIGLM
AIDDYEVRRL CCHYIVHYAE LNPAEAEGLL AFFARFVADL DPMLRSLAIK TVSDVPLRVF
SKMAFLLVPF LLVDQNPHVR TRAAFAVAKL YQHDAKTTVA HKLIESLNNL LYDDNQMVVA
NALAALHSIT ESLGSMGLSI NKDNLLRLMR SAAAANEWRQ VYLLNALMAY VPQSCQDAIE
VLETVVPALL HENAAVVLNG IKVILYLSNY IDTPELVVPG LPAKLGAVLV SLLSKPPELQ
FLVLRNIILL LLGKKYLMAV DVELFFWKFD DPIYIKDTKL EIIYLLANET NIDVVFRELE
EYATEVDSKM ARKAIRAFGN LALKSEAAAA SCVDILVDLI SNDISYIVQE ASVVIKNILR
KYPGKFSILL DSIVRHYKSM EDADAKLAIT WMVGQFCQQI PSADAILTHL LASFNEEPLD
VQYAMITAVV KYYVHFPHAG EALVLNVLKW ATEETDNPDL RDRGFFYWRL ITHLENGGAD
EEFQSRTKEI VININPEISS ESEKIDPMVL EELELNIGSL ASIYLKPVKH VFRLAKKKLL
PPSPALQPRR KPDLSYHVNS ATLQPIERPP RREHLKPLPL VDRNLSSSSF GTNSSRASAD
NSKKESFGQK LSRKASVMTW KKSMKH
//
