ID A0A1A0H6V6_9ASCO Unreviewed; 1733 AA.
AC A0A1A0H6V6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=METBIDRAFT_46054 {ECO:0000313|EMBL:OBA19685.1};
OS Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowia.
OX NCBI_TaxID=869754 {ECO:0000313|EMBL:OBA19685.1, ECO:0000313|Proteomes:UP000092555};
RN [1] {ECO:0000313|EMBL:OBA19685.1, ECO:0000313|Proteomes:UP000092555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-4993 {ECO:0000313|EMBL:OBA19685.1,
RC ECO:0000313|Proteomes:UP000092555};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., LaButti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA19685.1}.
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DR EMBL; LXTC01000006; OBA19685.1; -; Genomic_DNA.
DR RefSeq; XP_018710213.1; XM_018857985.1.
DR STRING; 869754.A0A1A0H6V6; -.
DR GeneID; 30030961; -.
DR OrthoDB; 1386981at2759; -.
DR Proteomes; UP000092555; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 986..1006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1083..1105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1194..1216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1273..1290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1335..1355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1361..1378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1390..1414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1484..1509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1528..1563
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 1733 AA; 200340 MW; 20B8C8CD91B72627 CRC64;
MRDSLDDSYF VSDHNTSLHG KSLGIFGPKS PFRNWCHKVV SHKFTNLAVT VIIFFQTVLL
AHRQWNPMKD YGYYFDGYSA GDYILVIINC LYTAEMAMKT VSYGLYDDRV MFKNLGMEYP
KRNSILGNSY FYSLLLEKVS HGIIYLRHLR STLSPNQSKS NKGQELSSMN DNTTSVYGIA
AQVSTREKFQ YPGLHISRSN NSISDRNDAL SSLSPSNPRR KGLFKLNTFF RLDYLSNVLG
DLQIKRAFLR DNWQRLDFIA ILSFWISLPM SLNHWDAAHH VMIFRALSCI RILRLCKLTD
GTNMILRACE SCLPQLIDVG IFIACFWFII GIVGVQSFKS SLTRHCVWTN PDDPSEVYID
TDLYCGSYLG TDGEIYSYLD RNGNHAAYPK GFRCPVNSVC QSGENPYNGT VNFDNILQSM
QMVFVMISVN TFSDIMYNLT DTDSLAASLF YIVGIFILTV WLMNIFTAII VSSFKNIQLE
AAEEQKRASG KLKKKTLIKQ IFNNEVHNNK VLELIEKKPL LKMYYRFEFI FILVIFASLI
TQMFRDSTMS EARAHKLYIV ESVFTLILLL EIIIRFTLYM PSVKTFFLSR GNCFDLILAT
ITSIMILGPV KNKLGHTYYW LTFFQCARFY RVVLSSRITS DLWIKIFRNF KPIYDLTLFY
FILLFLGGII VARYFEGTIP PDDVDTVIFA MHTLPNTLMS LYVITSTENW ANIMYGLQEY
ATSTFQRAMG SILLVLWFMI TNLIVMNIFI AVIAAPMEIS IEGRKKYQVR HFINDMTERL
QTVRVNPGWI QKLKSKAFKP KEEKNMEKAI TNLLLSGRAV NEFLDGDELA AERNQNDLET
HKNVIVRWWA SKLKSTKKFF QNPFYSKRSM ETDVSNFNPA EFATRVITER RKLISEQDQY
LKENPNFNTV FYVLGPRHKL RRLCQKIVPS SHGERIDGTE PNKIVAEIFS LFMFLSTIGI
VATACYQTPL YRSEMTQKFG KWNWTFYIDT CFMAIFTIEF FVKVVADGFL FTPNAYVRSS
WNWLDFGALG SLWIEFIAFL KNDSELSRIV RGLKALRALR ILTISETAKN NFHYTMISGF
GKILSAAIIS LTLLLPFSVW GLNIFNGRLG YCLDEASGVA ECYNEYRNEV YDWEIVSPKV
YVEPMLEFND FRSSFSSLYQ IVSLEGWSDL LVNVMQSTGV GTPQKMFASP VSGLFVILFN
FVSTVFILTL FVSVIINNYS KVTGRAYLTP VQVQWYHVKK FLLQVKPSQR KGAESLTGIR
KFCYMITVEK NRVWTFVLNS GLLLHIFVLL LEAFPSIVPN TFRYSCFMIV SSCFLAHFIM
LIIAQKLGGF IQNKWNVFSL LVVFGAWITT ILAFFINSDN LFINFNKMFL VGLLIFLFPR
SDRLNQLMKF ASASFPSLFS LIFTWFVIFI MYAIAMNQIF GMTKIGPNTS GNINLRSVPK
SLILLFRCSF GEGWNYIMDD FTLEEPFCQS GTSNGDSDCG SKEYAYFLFM SWNVISMYIM
LNLFVSLILD SFSYIAGGKQ YAHLISRPEI RKYKKCWQKF DPQGTGYISP QDLPRFLHLL
DGALSFHFYS GVLSVPELCS RWITRNSLTN PYDIDIDYSE INSILLMVNI SKIQERRKVY
EQFTEKAIMS MQLHEEPGIS FTKLLIQIPL YSSFNQNECL IFIDYMETDL MEKKVAERLR
KKRCYELIEG YACRWRFLRW KHGKILTEEF LKRDPQPLPE SLYQEDTYPD HLG
//
