ID A0A1A0H8P8_9ASCO Unreviewed; 1666 AA.
AC A0A1A0H8P8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=METBIDRAFT_32380 {ECO:0000313|EMBL:OBA20370.1};
OS Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowia.
OX NCBI_TaxID=869754 {ECO:0000313|EMBL:OBA20370.1, ECO:0000313|Proteomes:UP000092555};
RN [1] {ECO:0000313|EMBL:OBA20370.1, ECO:0000313|Proteomes:UP000092555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-4993 {ECO:0000313|EMBL:OBA20370.1,
RC ECO:0000313|Proteomes:UP000092555};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., LaButti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA20370.1}.
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DR EMBL; LXTC01000004; OBA20370.1; -; Genomic_DNA.
DR RefSeq; XP_018710892.1; XM_018856041.1.
DR STRING; 869754.A0A1A0H8P8; -.
DR GeneID; 30029017; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000092555; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000092555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 333..356
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1666 AA; 188464 MW; E68FA90114AB3565 CRC64;
MADIPINFTQ LSQLTQLGIQ PQLLDFKSTT LESDHYICVR ESGAQGNTVA IIDLHLNFEV
TRKNMSADNA IMHPKQNVIA LRANGTALQV FNLGSKQRLK SHTLESPVVL WKWLNDEFLG
LVTASSIYIW NVFDGTNNGP EKLSDRHHSL NNCQIINFVA EPNLNWFAVT GIAQEEGRIA
GHTQLFCKSR GVSQAIAGHV CKFAQIKLNG APHPTKVFCI GNKAALGQGS LHIIEIDHVD
GNPPFQKKIV DIFFPPDAAN DFPISLQASD KYGIIYILTK YGFIHLYDIE SGSNLFVNRI
TAEPVFTAAP YKDGTGIITI NKQGQVLAVE VAEDKIIPYV LEKLSDVPLG LSLASRGGFP
GAENLFNQQF QNYLNQGDYA NAAKVAASSE QLRTQDTINK LKHITPQPGQ ISPILQYFST
LLDRGSLNKY ESVELAKPVL QQDRKPLFEK WLKEDKLTSS EELGDIVKSY NDPALALAVY
IRANVNIKVV SCLAELGQFD KILPYCQKVG YQPDYTNLIQ NLVRVNPDKA SEFATSLLAN
DDSSLNIEST ADLFFSQNFI QQGTAFLLDA LKKDAPSDGH LQTKLLEVNL MHAPQVADAI
LGNQMFSHYD KPSIGRLCEK SGLFQRALEH YDDLKDIKRV IVHTNVLPND WLVSYFGQLN
VQQSMACLNE LMTHNMQQNL QVVIQVATKY SDLLGPLNLI KLFETYKCNE GLSYYLSMIV
NLTQDPDVVY KYIVAASKMN QIKEIERVVR DNNVYNGEKV KNFLKEAQLE DQLPLIIVCD
RFNFVHDLIL YLYKNKYFKF IEVYVQQVNP ANTPQVVAGL LDVDCDENII KSLLMSVLGR
VPLKELVSEV EKRNRLKILL PFLEKTLEGG STDQEVFNTL AKIYIDSNNS PEKFLEENNN
YDTLSVGKYC EKRDPYLAYI AYSKGGNDNE LINITNENKM YKYQARYLLR KSDFSLWEKV
LNSENEHRRL LIDHVILTGI PELSDPEPIS ITVKAFMEND LPQELIELLE KIILEPSPFN
DNTSLQGLLI LTAIKADPSR VANYIEKLDK FDAGEIAPLC IDNELLEEAF EVYDKFEMRD
EAMKVLVEDI MSLDRGEQYA EKYNTSDLWY QLGTAQLNGL RIPEAIESYV KSRNPQNFEQ
VIEIAERAGK EEELIPFLDM SRETLREPVI DNAVINCYAS LGKLSEIEKF VAGPNVAVLE
DIGDKLFEAK NYKAAKILYS NVSKYSKLAT TLVYLEDYQG AVDCARKASN TSVWKQVNSA
CIENKEFRLA QICGLNLIID AEELPELVKT YEHSGYFSEV ISLFESGLGL ERAHMGMFTE
LAILYSKYSP EKVMEHLKLF WSRINIPKVL TACEDAHLYP ELIFLYCHYE EWDNAALTMI
ERSEVAFDHS SFKEIIAKVS NLEIYYKAIN FYLAENPTLL VDLLSVLKSK IDLPRLVRMF
VKSDNLPLIK PFLISVLDKN NSIVNGAYHD LLIEEEDYKS LRSAIESESS NRFNSLDLAE
RLENHSLIFF RQISATLYTR HKKFNKAISI LKGDKLWADL IRTVGISGST KIAHEALDYF
VETGNHEAFA ALLYVGYDLV EYDYVLEISW LHDLSAFIKP YEISVAYENG QRLKEVYEDL
QRRKEKENAD DEPAAGQPLM ITNGPMMGQT TGLGYQPTGA GFGNAF
//
