ID A0A1A0HG31_9ASCO Unreviewed; 491 AA.
AC A0A1A0HG31;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Ribosomal lysine N-methyltransferase 4 {ECO:0000256|PIRNR:PIRNR011771};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR011771};
GN ORFNames=METBIDRAFT_35924 {ECO:0000313|EMBL:OBA22813.1};
OS Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowia.
OX NCBI_TaxID=869754 {ECO:0000313|EMBL:OBA22813.1, ECO:0000313|Proteomes:UP000092555};
RN [1] {ECO:0000313|EMBL:OBA22813.1, ECO:0000313|Proteomes:UP000092555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-4993 {ECO:0000313|EMBL:OBA22813.1,
RC ECO:0000313|Proteomes:UP000092555};
RG DOE Joint Genome Institute;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goker M.,
RA Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K., Choi C.,
RA Clum A., Coughlan A.Y., Deshpande S., Douglass A.P., Hanson S.J.,
RA Klenk H.-P., LaButti K., Lapidus A., Lindquist E., Lipzen A.,
RA Meier-kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J., Peng Y.,
RA Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C., Stielow J.B.,
RA Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V., Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC methyltransferase that monomethylates 60S ribosomal protein L42.
CC {ECO:0000256|PIRNR:PIRNR011771}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR011771}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC {ECO:0000256|PIRNR:PIRNR011771}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA22813.1}.
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DR EMBL; LXTC01000001; OBA22813.1; -; Genomic_DNA.
DR RefSeq; XP_018713294.1; XM_018856671.1.
DR AlphaFoldDB; A0A1A0HG31; -.
DR STRING; 869754.A0A1A0HG31; -.
DR GeneID; 30029647; -.
DR OrthoDB; 51002at2759; -.
DR Proteomes; UP000092555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR InterPro; IPR011383; N-lys_methylase_SETD6.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR13271:SF34; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR Pfam; PF00856; SET; 1.
DR PIRSF; PIRSF011771; RMS1_SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PIRNR:PIRNR011771,
KW ECO:0000313|EMBL:OBA22813.1}; Nucleus {ECO:0000256|PIRNR:PIRNR011771};
KW Reference proteome {ECO:0000313|Proteomes:UP000092555};
KW S-adenosyl-L-methionine {ECO:0000256|PIRNR:PIRNR011771};
KW Transferase {ECO:0000256|PIRNR:PIRNR011771}.
FT DOMAIN 23..262
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 491 AA; 56248 MW; 9A33F95F2BF7B2C5 CRC64;
MLFDERTLSF LTWLMQNAVT TSPKIRISDF RSSGQGRCVV ATDEIMEDEE LFSIPRSAIL
NVQSSSLAKE HAGAELVLAQ MTQWDALVLV LLYEWKVKAT SLPWWEYFNV LPLNDESYAS
NQLIYWDDTE LSHLAPSYIV DRIGHNSANA MYDRLVPHFE KFVGTVTKDE FRKVASVIMS
YSFDVGSKDV DDDEDNDEVS DDEVESNLVK DSDYLKSMVP LADTLNADTA KHNASLFITA
DHLVMRSIKP IAKNDQIYNI YAEHPNSEIL RRYGYVEQQG LAHDFAEVSL ATFKKYFAEN
SSLSKDTIDE ILAILEEIEI EEDEKFVLES YDCFGSGEVI FELTFLTQLF VIIAAINHKK
SFNSASLEVK ARAIRRVYKK TYQLLESRRL TKQFMKDFPS ILKVRLSEYP RKATRGFSPS
RDTPLTRQEM AMAVLTSECV SLQNCMDTEK VFTKGEQEFS VIDDEKLLRN IMQKNTFEGS
ETQPSKKKRM S
//
