ID A0A1A0M5P8_9MYCO Unreviewed; 393 AA.
AC A0A1A0M5P8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Thiamine pyrophosphokinase {ECO:0000313|EMBL:OBA80715.1};
GN ORFNames=A9W99_15665 {ECO:0000313|EMBL:OBA80715.1};
OS Mycobacterium sp. 1164966.3.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1856861 {ECO:0000313|EMBL:OBA80715.1, ECO:0000313|Proteomes:UP000092060};
RN [1] {ECO:0000313|Proteomes:UP000092060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1164966.3 {ECO:0000313|Proteomes:UP000092060};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Garcia-Basteiro A.,
RA Lopez-Varela E., Palencia S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA80715.1}.
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DR EMBL; LZSG01000040; OBA80715.1; -; Genomic_DNA.
DR RefSeq; WP_067378549.1; NZ_LZSG01000040.1.
DR AlphaFoldDB; A0A1A0M5P8; -.
DR STRING; 1856861.A9W99_15665; -.
DR OrthoDB; 5169996at2; -.
DR Proteomes; UP000092060; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR InterPro; IPR047795; Put_SteA-like.
DR InterPro; IPR022215; SteA-like_C.
DR InterPro; IPR036759; TPK_catalytic_sf.
DR NCBIfam; NF040608; division_SteA; 1.
DR Pfam; PF12555; SteA-like_C; 1.
DR SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OBA80715.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000092060};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 348..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..382
FT /note="SteA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12555"
SQ SEQUENCE 393 AA; 42306 MW; 9247B8EB6115ED7F CRC64;
MRMSTLLTRN TTRPGIVGTA RVDRNIDRLL RRVCPGDIVV LDILDLDRIT ADALVEADIA
AVVNASPSVS GRYPNLGPEV LVNNGVTLID ETGPEVFKKV KDGAKIRLHE GGVYAGDRRL
VRGTQRTDHD IADLMREAKG GLAAHLEAFA GNTIEFIKSE SPLLIDGIGI PDIDVDLRRR
HVVIVADEPT AADDLRALKP FIKEYQPVLV GVGTGADVLR KAGYRPQIIV GDPDQISTDA
LKSGAQVVLP ADADGHAPGL ERIQDLGVGA MTFPAAGSAV DLALLLADHH GAALLVTAGH
TANIETFFDR TRTQSNPSTF LTRLRVGEKL VDARAVATLY RNHMSGGAIA LLALTMLIAV
IVALWVSRTD ATVLHFVVDY WNRSSFWVQH LVS
//
