ID A0A1A0M726_9MYCO Unreviewed; 393 AA.
AC A0A1A0M726;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OBA81279.1};
GN ORFNames=A9W99_13855 {ECO:0000313|EMBL:OBA81279.1};
OS Mycobacterium sp. 1164966.3.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1856861 {ECO:0000313|EMBL:OBA81279.1, ECO:0000313|Proteomes:UP000092060};
RN [1] {ECO:0000313|Proteomes:UP000092060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1164966.3 {ECO:0000313|Proteomes:UP000092060};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Garcia-Basteiro A.,
RA Lopez-Varela E., Palencia S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA81279.1}.
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DR EMBL; LZSG01000035; OBA81279.1; -; Genomic_DNA.
DR RefSeq; WP_067377541.1; NZ_LZSG01000035.1.
DR AlphaFoldDB; A0A1A0M726; -.
DR STRING; 1856861.A9W99_13855; -.
DR OrthoDB; 9786288at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000092060; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000092060}.
FT DOMAIN 33..235
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 255..389
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 175
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 393 AA; 41846 MW; E243703CD59E78D1 CRC64;
MSVSKGGAPQ PESCEQQGHS LAELPPSPPT TVAVIESIAT GTPQRLVNQC EAADRVGGLF
NDPVQRDRIR RVYAKTKVVT RRMAVDPLDA EFESFRRNPA TIRDRMDLFH RHAVPLAVEV
GGRALGALPY ATDEVGLLVF VTSTGFIAPG VDVAIVRELG LSRSVSRVVV NFMGCAAAMN
AVRIAASYVR AHPDLKAMVV CVELCSVNAV FADDVNDVVT HSLFGDGCAA LVIGASQVHE
RLEPGKVVIR TSFSRLLDGA SDGIVLGVNP NGITCELSES LPDYIYAGVA PVVAEMLADN
GLQKSDIDLW AIHPGGPRII EESVRSLAIP PERAAPSWDA LAGFGNMLSV SLIFVLETMV
RQPESGKEIS TGVALAFAPG VTVEGMLFDI IRR
//
