ID A0A1A0MEP7_9MYCO Unreviewed; 927 AA.
AC A0A1A0MEP7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=A9W99_05820 {ECO:0000313|EMBL:OBA83914.1};
OS Mycobacterium sp. 1164966.3.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1856861 {ECO:0000313|EMBL:OBA83914.1, ECO:0000313|Proteomes:UP000092060};
RN [1] {ECO:0000313|Proteomes:UP000092060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1164966.3 {ECO:0000313|Proteomes:UP000092060};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Garcia-Basteiro A.,
RA Lopez-Varela E., Palencia S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA83914.1}.
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DR EMBL; LZSG01000005; OBA83914.1; -; Genomic_DNA.
DR RefSeq; WP_067372892.1; NZ_LZSG01000005.1.
DR AlphaFoldDB; A0A1A0MEP7; -.
DR STRING; 1856861.A9W99_05820; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000092060; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..353
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 434..749
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 764..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 927 AA; 99478 MW; 63167D01B0B1AB72 CRC64;
MFAWWGRTVY RYRFIVIGVM VVLCLGGGIF GMSLGKHVTQ SGFYDEGSQS VKASVLGDQT
YGRDRTSHIV ATFTAPDGKT VDDPAWRKKI IDELNKFKSD HSNEVLGWAG YLALSNPADA
PPLIKGMATE DKKHTFVSIP LKGNDDDTIL NNYKSIEPAL QKLDGGTVEL AGLEPIANAL
TGTIATDQRR MEVLALPLVT VVLFLVFGGA VAAGLPVIVG GLSIAGALGI LRLISLFGPV
HFFAQPVVSL IGLGIAIDYG LFIVSRFREE IAEGYDTEAA VRRTVMTAGR TVVFSAVLII
ASSASLLVLP QGFVHSLTYA IFAAVGLAAL LSITLLPASL GILGRHVDAL GVRTAFRVPF
LRNWKVSRAY LNWLADRLQK TKTREEVEAG FWGKLVNWVM KRPLAFAIPI AVGMILLVIP
LGNLHFGGMS EKYLPPNNGV RLAQEHFDKL FPGYRTEQLT VVIQSNNRSP VTDQQVADVR
SKVAGITGFT NQQWDERPCP IVAGNPCAAE PNGTSHPEDK TVRVIQNGLV NRNEAAKKID
ELRAITPPKG VSVLVGGTPA LEQDSIHSLF DKAPLMLVIL LTATLLLMFL AFGSVVLPVK
AAVMSALTLG STMGILTWIF VDGHFATLLN FTPTPLMVVL IALVVAVGFG LATDYEVFLV
SRMVEARERG YSTAEAIRIG TATTGRLITA AALVLAVVAG SFVFSELVLM KYLAFGLMAA
LLLDATVVRM FLVPSVMKLL GDDCWWAPRW ARRLQNRIGL GEIDLPDEHK RPTLEGRAVR
PPVTASAVAA QAQRPHHDPT HPSAPEPPRP TRAAPTATEK PSGAATGRMP TAPQGSAQAP
GSSRPASPTP SADRTQRIPV PSSHAGDSNG DPAEPTAALP VMRSETDDSE AATEKLNAQG
EGDKARPRRR VGGGVSAQEL LRREGRL
//
