ID A0A1A0TAT9_9MYCO Unreviewed; 294 AA.
AC A0A1A0TAT9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:OBB55976.1};
GN ORFNames=A5757_02745 {ECO:0000313|EMBL:OBB55976.1};
OS Mycobacterium sp. 852013-51886_SCH5428379.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834111 {ECO:0000313|EMBL:OBB55976.1, ECO:0000313|Proteomes:UP000091910};
RN [1] {ECO:0000313|Proteomes:UP000091910}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=852013-51886_SCH5428379 {ECO:0000313|Proteomes:UP000091910};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Mehaffy C., Tameris M.,
RA Hatherill M., Hanekom W., Mahomed H., Mcshane H.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBB55976.1}.
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DR EMBL; LZSU01000051; OBB55976.1; -; Genomic_DNA.
DR RefSeq; WP_066838063.1; NZ_LZSU01000051.1.
DR AlphaFoldDB; A0A1A0TAT9; -.
DR STRING; 1834111.A5757_02745; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000091910; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000091910}.
FT DOMAIN 3..154
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 160..281
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 166
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 294 AA; 30176 MW; F0503502D69F1945 CRC64;
MDLGFVGLGN MGAPIAARLI AAGHRLTVFD IDAAAVARTV GQGAVAAGSP TEVAERAATV
LMSLPTPKTS EEVVAAVAAG SRVERLIDLS TTGSAAAVRN RERLDARGAG MLDCPVSGGV
AGATNGALTV MVSGPRALFD SARDVLETLG RPLFVGEKPG AAQTMKLVNN LMAACSLAAT
AEVAVMGVKS GLDPTVMIEV LNAGSGATHA SRDKFPRSIL PRTFDYGFAT GLMVKDLRLY
LEEAQALSLP TALASTVLQV WETVLTQQGP DSDFTSVVKP YEAAAGVVVD GRPR
//
