ID A0A1A0U0N5_9MYCO Unreviewed; 390 AA.
AC A0A1A0U0N5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:OBB64592.1};
GN ORFNames=A5758_20350 {ECO:0000313|EMBL:OBB64592.1};
OS Mycobacterium sp. 852014-50255_SCH5639931.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834112 {ECO:0000313|EMBL:OBB64592.1, ECO:0000313|Proteomes:UP000092113};
RN [1] {ECO:0000313|EMBL:OBB64592.1, ECO:0000313|Proteomes:UP000092113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=852014-50255_SCH5639931 {ECO:0000313|EMBL:OBB64592.1,
RC ECO:0000313|Proteomes:UP000092113};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBB64592.1}.
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DR EMBL; LZSV01000032; OBB64592.1; -; Genomic_DNA.
DR RefSeq; WP_067206165.1; NZ_LZSV01000032.1.
DR AlphaFoldDB; A0A1A0U0N5; -.
DR STRING; 1834112.A5758_20350; -.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000092113; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08283; FDH_like_1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..148
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 196..264
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 390 AA; 41974 MW; 3593CECDB6C81526 CRC64;
MKATVWAGRN SVQVESVPDP KILNDRDAIV RITSTAICGS DLHLYDGYIP TVKHGDVLGH
EFMGEVVEVG KAVNNLAIGD RVVVPFPIAC GACSACRRDL YSLCENSNPN AGIAEKFMGH
SPAGLFGYSH MLGGFAGGQA EYARVPFADV GPLKIEDDLT DEQVLFLSDI LPTGYMGAEM
CNITPGDVVA VWGAGPVGLF AIMSAFLLGA SKVIAVDRVP YRLELAKQIG ATPVNFAETS
VLEELRDITA GRGPDHCIDA VGMEARSGSA PVDAYDRVKQ AARLETERPH AIREAAMSCR
NGGTLSIVGV YGGLMDKFPI GAVMNRSLTI KTGQCHVHRY MRPLLDRIRN GDIDPTIVVS
HHLSLDQAPH GYEIFKNKED RCTKVILNPT
//
