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Database: UniProt
Entry: A0A1A1WWH5_9MYCO
LinkDB: A0A1A1WWH5_9MYCO
Original site: A0A1A1WWH5_9MYCO 
ID   A0A1A1WWH5_9MYCO        Unreviewed;       532 AA.
AC   A0A1A1WWH5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   16-JAN-2019, entry version 13.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:OBF11252.1};
GN   ORFNames=A5727_20100 {ECO:0000313|EMBL:OBF11252.1};
OS   Mycobacterium sp. ACS4331.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1834121 {ECO:0000313|EMBL:OBF11252.1, ECO:0000313|Proteomes:UP000092314};
RN   [1] {ECO:0000313|EMBL:OBF11252.1, ECO:0000313|Proteomes:UP000092314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACS4331 {ECO:0000313|EMBL:OBF11252.1,
RC   ECO:0000313|Proteomes:UP000092314};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OBF11252.1}.
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DR   EMBL; LZHW01000103; OBF11252.1; -; Genomic_DNA.
DR   RefSeq; WP_068256652.1; NZ_LZHW01000103.1.
DR   EnsemblBacteria; OBF11252; OBF11252; A5727_20100.
DR   Proteomes; UP000092314; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000092314};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:OBF11252.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092314};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     12     37       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    210       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      212    264       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      300    519       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   COILED      263    297       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   532 AA;  59101 MW;  B874BF564575D809 CRC64;
     MRRHRWQLTV QGWLVVVLSV MGAVVLVGAG FAGYLLYRAD QVSHELSEDI QPARVAAYRM
     QAAIRDQETA LRGYLISADR DFLVPYYDGI RAEADAAAEI RDHVADRPTL IADLDAIQQA
     AARWRADYAE PAIRSVTPGE TSVIDARDLQ TGKAEFDRIR SMFDGQSQHL TDIRSEWIVD
     LDRAQSWRNW VLLGVLLVFL VTSALLAVLV RSAVTRPLEA LAAACRRITE GHFNERIVPQ
     GPKDIRAIAA DVEDMRQRIV DELEVSRAAR QALAEQAEAL DEQAIELRRS NAELEQFAYV
     ASHDLQEPLR KVASFCQLLE KRYGGKLDDR GHEYIKFAVD GAKRMQILIN DLLAFSRVGR
     LNSTLAEVDL GAALDVAVDN VATAIEESEA EIIRPERPLP TVTGDPTLLT MLWQNLVSNA
     VKFRRPDERP RIVVTCESSL GEESMHLLTV TDNGIGIGEE FAEKVFVIFQ RLHGRDAYTG
     TGIGLALCKK IVEYHGGGIW IDTSHTEGTR ICFTLPRVVD VPAATAEEGT TV
//
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