ID A0A1A1Y6X2_9MYCO Unreviewed; 1584 AA.
AC A0A1A1Y6X2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OBF27069.1};
GN ORFNames=A5724_03175 {ECO:0000313|EMBL:OBF27069.1};
OS Mycobacterium sp. ACS1612.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834117 {ECO:0000313|EMBL:OBF27069.1, ECO:0000313|Proteomes:UP000092025};
RN [1] {ECO:0000313|Proteomes:UP000092025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACS1612 {ECO:0000313|Proteomes:UP000092025};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Kiyimba A., Mayanja H.,
RA Musoke P., Ssengooba W., Joloba M.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBF27069.1}.
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DR EMBL; LZHZ01000067; OBF27069.1; -; Genomic_DNA.
DR RefSeq; WP_067810499.1; NZ_LZHZ01000067.1.
DR STRING; 1834117.A5724_03175; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000092025; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092025};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..82
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 99..524
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1477..1552
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 936..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1584 AA; 168464 MW; B26E4ED1A9FCA1C0 CRC64;
MTAAFDEERL RHWLVDYLVT NIGCSPDDID LDASMNDLGV GSRDAVVLAG ELSELVGRQI
SPVEFWQHPR IGELAEFLSG SEADTDAGLV LEHDRGSGDE PIAVIGLGCR LPGAIAGPEA
LWQFLREGRS AVDEVPPDRW APYDDGSPAV AAALSQTTRW GSFLSDIDAF DAEFFDISRR
EAAKMDPQQR LLLEVAWEAL EHTGIRASSL RRSQTGVYVG ASITEYGYLA STDLPNVDAW
SNPGGALSII ANRLSYFLDL RGPSVTVDTA CSSSLVALHL ACQGLRMHDS DMAIAAGVNL
LMSPAVFRGF DQSGALSPTG ACHAFDAEAD GFVRGEGCGV VVLKRLSDAV RDGDRLLAVV
RGSAVNQDGR SNGLLAPNPA AQMAVLRAAY TNAGVPPHEV DYVETHGTGT NLGDPIEARA
LGTVLGRGRA EQSPLLIGAI KSNLGHLEAA AGIVGFIKAV LAVERASIPA NLHFHTPNPH
IAFDQMRLKV VAEQQEWPPT RRPRRAGVSS FGFGGTNAHV VIEQAPTSVP VIRESDPAVT
TLVVSGKSPE RIASMAASLA EWMAGAGAEV PLPDVAHTLN HHRDRHAQFA TVCARDRAEA
VTGLQALAAG RSADGVVGPH EGSCRAGTVF LYSGQGSHWA GMGRQLLADE PVFAAAIAEL
EPVFVEQVGF SLQRVIAEGA PVSGDARVQP VLMGLQLALT ELWRSYGVHP DAVIGHSMGE
VSAAVVAGAL NVADGLRVIA TRSRVMSQLT GQGAVALLKL DAEATATLIA DFPGVSLAGY
LSPRQTVIAG PVAPVEAVIA AVSAQNRFAR RVNMEVASHT ALMDPILPEL RSALEDLTPD
IVTIPFFSTV AEATVPMLDA EYWAANVRQP ARVSQAIMAA AEEHATFIEI SAHPILAHAV
SDTLETVTHH HSLGTLLRDG DDTVSFHTNL NRIHTSHPPQ IPHPHEPHPV LPTTPWHHSR
HWFSPTSPDS AKRNERNGDS GVPTGKGVPA EWYCELTWPA RRLPDAQTNV DSWWLVFGDP
GLGAEIGRVL GDDSRVTVLP PSMVAEHTDK TALAKALAGV THVLYAPQLS TSGYFDAELG
YGVFNSARRL MAAVAATSLP PRLYLLTRNG QPVHEGDRAN PAHAVLWGLG RTAALEHPEI
WGGIIDVDAS VPEGVAARYV LDEAGGGDED QVVYRAGTRR VPRLGKGLPP STSPVELDKD
SSHLVIGATG NIGPHLIRQL ADMGAGTVVA VSRNPGSRLD ELAARLAAAG TTLVTVAADA
ADESAMNTLF DRFGTDLPPL AGIYLAAFGG GPVTLRDMTD DDVAAMFRPK LNVAALVHKL
SLRHSVHQFV LFTSISGVTG SRWLAHYAAT TTFLDAFAYA RRAAGLSATA INWGLWKSLT
DIQSDQERQV TLDSGLQPMP DEVAIQALAS LTGKDAPVRS TIVSADWSRL ATAYRTRAAL
HIVDDMMPTD AQSDTSSVLR TEFREALRDC EPTRRHRLLV DHVTAQVAAA MGLASPQLLD
PSAGFFQSGM DSLMSVTLQR SLGDSVGEAL PASVVFDYPT VDALVGYLAT ILPELIEVAE
DDSADDYEDL SDDELLQQLS ERLG
//
