ID A0A1A2BE94_9MYCO Unreviewed; 488 AA.
AC A0A1A2BE94;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:OBF66390.1};
GN ORFNames=A5753_06665 {ECO:0000313|EMBL:OBF66390.1};
OS Mycobacterium sp. 852002-51971_SCH5477799-a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834106 {ECO:0000313|EMBL:OBF66390.1, ECO:0000313|Proteomes:UP000091887};
RN [1] {ECO:0000313|EMBL:OBF66390.1, ECO:0000313|Proteomes:UP000091887}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=852002-51971_SCH5477799-a {ECO:0000313|EMBL:OBF66390.1,
RC ECO:0000313|Proteomes:UP000091887};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBF66390.1}.
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DR EMBL; LZIF01000063; OBF66390.1; -; Genomic_DNA.
DR RefSeq; WP_067124938.1; NZ_LZIF01000063.1.
DR AlphaFoldDB; A0A1A2BE94; -.
DR STRING; 1834106.A5753_06665; -.
DR Proteomes; UP000091887; Unassembled WGS sequence.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProt.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR CDD; cd07089; ALDH_CddD-AldA-like; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR42804; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42804:SF1; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 15..481
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 488 AA; 51228 MW; A6B07D639E3A365E CRC64;
MTIVAEQRTY VAGSWITGDD VVSVENPADE SHVADITATP LPEVRRAIAE ARRSFDDGVW
ADAPPSERAR VLHALIDHVE AARDALVPTL VAEAGQSKFF AEMTQLRAGA AIGRHTIDLY
QSMSHEEASP VPVDDLVRGR VALSIRRHEP VGVVTAITPY NAALIMGFQK LIPALMAGNS
VILRPSPLTP ISSLIFGAAA DAAGLPPGVL SVVVESGIAG AELLTSDPGV DMVSFTGSTL
AGRRILAQAA PTVKRVSLEL GGKSAQIYLP DAVHRAAGGA FVAVASTAGQ ACVAATRMLV
PQDKKDEVLD AVSAMYKLIK VGPPSDESAM MGPVISAAQR DKCEKYVKLA EEHGGKVFCG
GGRPAGLDRG YYFEPTVLDL PTNANPAAQE EIFGPIIGVL GYRDIDDAVA IANDSIYGLS
GQVYGTDAAA ALQVARRLRT GAVNVNTTVF SAYAPSGGYK QSGLGRERGP DGIREFQEVK
HMSIGELK
//
