ID A0A1A2G663_9MYCO Unreviewed; 4176 AA.
AC A0A1A2G663;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OBG24534.1};
GN ORFNames=A5764_08980 {ECO:0000313|EMBL:OBG24534.1};
OS Mycobacterium sp. 852002-51057_SCH5723018.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834094 {ECO:0000313|EMBL:OBG24534.1, ECO:0000313|Proteomes:UP000092171};
RN [1] {ECO:0000313|Proteomes:UP000092171}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=852002-51057_SCH5723018 {ECO:0000313|Proteomes:UP000092171};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Mehaffy C., Tameris M.,
RA Hatherill M., Hanekom W., Mahomed H., Mcshane H.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBG24534.1}.
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DR EMBL; LZIR01000075; OBG24534.1; -; Genomic_DNA.
DR RefSeq; WP_067114436.1; NZ_LZIR01000075.1.
DR STRING; 1834094.A5764_08980; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000092171; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd05195; enoyl_red; 2.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00829; PKS_ER; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..457
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1978..2053
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2071..2495
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4020..4095
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT COILED 2..32
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4176 AA; 433992 MW; 893A128547E41C91 CRC64;
MVDQLQHATE ALRKALVQVE RLKRTNRALL ERSSEPIAIV GMSCRFPGGI DTPEGLWQMV
ADGRDVISDF PTDRGWDLPG LFDPDPDARH KCYVRTGGFV DGVGDFDPAF FAIAPSEALA
MDPQHRMLLE LSWEALERAG IDPTGLRGSA TGVFAGLIVQ GYGMLAEEIE GYRLTGMTSS
VASGRVSYVL GLEGPAVSVD TACSSSLVAL HMAVQSLRTG ECDLALAGGA TVNATPTVFV
EFSRHRGLAP DGRCKAYAGA ADGVGWSEGG ALLVVERLSD ARRLGHPVLA VVRGSAVNQD
GASNGLTAPN GPSQQRVVRA ALANAGLSAA DVDVVEGHGT GTTLGDPIEA QALLATYGQD
RAEPGTPLWL GSIKSNMGHT QAAAGVAGVI KMVQAMRHET LPATLHVDAP SPHVDWSAGS
VSLLTEPRPW SADGRLRRAG VSSFGISGTN AHVIVEAAPE PQPRDAAPAL PVVPWVISAK
SASALASQAS RLADHVRAHG DLDIADVAWT LAGRSNFEHR AVVVGGDRDR LLAGLDELAA
DDLGGSVIRG TAAPAGKNVF VFPGQGSQWL GMGIELLDTA PVFAQQIEAC AEAFAEFVDW
SLTDVLRGAP GAPGLDRVDV VQPVLFATMV SLAELWKSVG VSPDAVIGHS QGEIAAAYVA
GALSLRDAAR VVTLRSKLLR SLAHPGGMLS IACSTERARE LLAPYGNRVS IAAVNGPSAV
VVSGEVAALE ELVGFCADLD LRTRRIDVDY ASHSVEVEAI RGELAEALAG IEPRSSRVAF
FSTVTGSRLD TAGLDAAYWY RNIRQTVQFD QAVRSACEHG YRTFIEASPH PALIAGIEDT
FNDCVTGDAE PIVVPTLGRD EGGLERFLTS AAAAFVAGAG VDWRGVVGGA GFVELPTYAF
ERRRFWLSGE GAGADAAGLG LGISEHALLG AVVELPASGG VVLTGRLSPG AQGWLADHAV
SGVLVFPGAG FVELAIRAGD EVGCSVVDEL TLQAPLTLPT SGSVAVQVVV GPAEETRRRA
VSIYSRADAD AGSAWVCHAE GALSSQPVEP GVDLSVWPPA GAVAVDLADG YERLAARGYG
YGPAFQGLTA AWVRGDEVFA EVRLPDAAGG VGGFGVHPAL LDAAMHAVVM ADSAGQETEV
LLPFSWQGVS LHAAGAAAVR ARIAPTGRPA GSPAVSIELA DGLGLPVLSV AAMVARSVSE
RQLRAAVSGS GPDRLFEVVW SAGAKTPTSG GSVPSFEVFE SVAAEGDPVS ATYERTHRAL
TALQSWLTDR DSGVLVVATR GAAAMVGEDV TDLAGAAVWG LVRSAQTEHP GRIVLVDSDV
PLDDAAGAAL VTAIVAAGEP QVLVRGGQVY LPRVHGSRGV EGILAPPGDG PWRLGLSSAG
TFENLRLEPV PNADAPLQPG QVRVAVRAIA ANFRDVMITL GMFTHDALLG GEGAGVVVEV
GPGVTEFAVG DSVYGFFPDG SGTLVPGDVR LLLPMPSDWS YAEAAAISAV FTTAYMAFVH
LADVKPGQRV LVHAAAGGVG MAAVQLARHL GLEVFGTASR GKWDTLRAMG LDDDHISDSR
SLEFEDKFRT ATGGRGFDVV LDSLAGEFVD ASLRLVAPGG VFLEMGKTDI RDPGVVAQEY
PGVRYRAFDL FEPGRPRMHQ WMLELAELFD AGVLQPLPVT TFDVRRAPAA LRYLSQARHI
GKVVMTLPGG GLAAGTVLIT GGTGMAGSTL ARHLVAQHGV RNLVLLSRRG RDAVGSAELV
AELQAAGAQV RVVACDAADR AALAAVLDDI PEQHPLSGVI HAAGVLDDAL VTSLSPERVD
AVLRAKVDAA WNLHELTRDR DMSAFVMFSS MAGLVGSSGQ GNYAAANSFL DAVAAHRRAH
GLPAISLAWG LWDQASAMTG GLDAADLARL GRDGILALSS DEAMELFDTA LILDEPFLAP
ARIDLATLRA NAAAVPPMFT DLVNAPLRRQ VDDSLAAAKS KSALAHRLHG LPEAEQHAVL
LDLVRSHIAT VLGNTAPEAI DPDKAFQDLG FDSLTAVEMR NRLKAATGLA LSPTLIFDYP
TPNGLAGYIR GELAGVPQEI AAAPVVQATG DDPIVIVGMA CRYPGGVASP DDLWDMLTEG
RDVLSEFPTD RGWNLADLYD PDPDVPGTCY TRTGGFVDGV ADFDPAFFGI APTEALAMDP
QQRMFLELSW EALERAGIEP GALRGSATGV FAGVYTQGYG IGAPPAAEGF RLTGQSSSIA
SGRISYVLGL EGPAVSVDTA CSSSLVALHM AVQSLRSGEC DLALAGGVTV NATPDIFVEF
SRMRGLSADG RCKAFAGAAD GTGFSEGGGM LVVERLSDAR RLGHPVLAVV RGSAVNQDGA
SNGLTAPNGP SQQRVVRAAL ANAGLSAADV DVVEGHGTGT MLGDPIEAQA LLATYGQGRA
EPLWLGSIKS NMGHTQAAAG VAGVIKMVQA MRHETLPATL HVDEPSPHVD WSAGSVSLLT
EARPWKPEQA NGHVRRAGVS SFGISGTNAH VIIEAVPSDR VVDRPKLPAV PWVVSAKSAS
ALASQAARLA DHVRGHGDLD IADVAWTLAG RSNFEHRAVV VGDDRDRLLA GLDGLAAADL
SGSVIQGTAT AGGKTVFVFP GQGSQSLGMG MGLHAGYPVF AEAFNTVVAE LDRHLLRPLR
EVMWGHDESL LNTTEFAQPA LFAVEVALFR LLESWGVRPD FVMGHSVGEL TAAHVAGVLS
LENAAVLVAA RGRFMQALPP GGAMVAVQAT EEEVRPLLDG EVGIAAVNGP ASVVISGAEE
AVAALADRLR AEGRRIHRLA VSHAFHSPLM EPMIDEFGTV AAGLAIGRPS IPLVSNLTGQ
LAGDDFASVA YWQRHIREAV RFADSVRFAH SAGVTRFLEV GPSGGLTASI EESLPDTPVV
TTSALRKDRP EPATLLNVVA QGFVTGMDVN WRAALGQANL VELPTYAFER RRFWLAADGA
PADAAGLGLQ ASEHALLGAV VELPATGGVV LTGRLSPATQ AWLADHAVGG VVLFPGAGFV
ELAIRAGDEV GCGVVDELNL AAPLVLPTAG SVAVQVVVGG PDDAGARAVS VFSRAETGSG
WLLHAEGVLS AGSVEPSAEL SAWPPVGAVP VDVGDGYERL AERGYRYGPA FRGLTSMWRR
GDEVFAEVAL PADAGVSVAG FGVHPVMLDA ALHAVILASD DGELAEGSVL VPFSWQGVSL
HAAGASAVRA RIVRTGPAGS PAVSIELADG LGLPVLSVSS MVARPVSDRQ LLAAVSNAGP
DRLFEVIWSA QPSAAVQPVL VQRWGTTESA DVEPGAMLFE SAPVMGDVVS GVRAATRSVL
EVLQSWLARD GSATLVVSTH GAAALPGEDV TDLAGAAVWG LVRSAQTEHP GRIVLADTDV
PLDDDAIAAA LAVGEPQVVL RDGTAYTARV HGSRAVSAVL VPPGEGPWRL GMSSHGTFEN
LRLERIPNAD APLGPGQVRV ALSAIAANFR DVMIALGLYP DPDAVMGVEA SGVVIECATE
DGRFAVGDRV MGLFPEGTGT VACTDERLLV KVPVGWSHTA AATTSVVFAT AFYALVDLAR
VKPGQRVLVH AAAGGVGMAA VQLARHFGLE VFATASHGKW NTLRAMGFDE DHIADSRSCE
FEDKFRAVTG GHGFDVVLDS LAGEFVDASL RLVAPGGVFL EMGKTDIRDA DAIAAEYPGV
RYRAFDLFEA GPDRIQQMLA ELAGLFGEEV LRPLPVTTFD VRRAPAALRY LSQARHVGKV
VMTLPTAPGG WLGAGTVLIT GGTGMAGSAL ARHVVARHGV RNLLLLSRRG PDAPGAAELT
AELTAAGAAV QVVACDAADR EALAKVVADI PVQRPLSAVI QAAGALDDAV VMSLTPERMD
AVLRSKVNAA WNLHEVTRDL DVSAFVMFSS MAGLVGSSGQ GNYAAANSFL DGLAVHRRAH
GLPAVSVAWG LWDQASSMTG GLATVDFARF ARDGIVAMSS DEALQLLDTA MIVDEPFMLP
AHIDFAALRV KFDGGTLPPM FVDLINAPTR RQVDDSLAAA KSKSALLQRL EGLAEDEQQA
ILLDLVRSNI ATVLGSGSPE AIDPDRAFQE LGFDSLTAVE MRNRLKSATG LPLSPTLIFD
YPNSAALAGY MHRELVGASD QLAPAAAPGE AEIQRVVGSI PVKRLRQAGV LELLLALANE
GEGGRQAAVP AAGSEKDIAD MDLDDLVNSA LLDDDE
//