GenomeNet

Database: UniProt
Entry: A0A1A2G663_9MYCO
LinkDB: A0A1A2G663_9MYCO
Original site: A0A1A2G663_9MYCO 
ID   A0A1A2G663_9MYCO        Unreviewed;      4176 AA.
AC   A0A1A2G663;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OBG24534.1};
GN   ORFNames=A5764_08980 {ECO:0000313|EMBL:OBG24534.1};
OS   Mycobacterium sp. 852002-51057_SCH5723018.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1834094 {ECO:0000313|EMBL:OBG24534.1, ECO:0000313|Proteomes:UP000092171};
RN   [1] {ECO:0000313|Proteomes:UP000092171}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=852002-51057_SCH5723018 {ECO:0000313|Proteomes:UP000092171};
RA   Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Mehaffy C., Tameris M.,
RA   Hatherill M., Hanekom W., Mahomed H., Mcshane H.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBG24534.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LZIR01000075; OBG24534.1; -; Genomic_DNA.
DR   RefSeq; WP_067114436.1; NZ_LZIR01000075.1.
DR   STRING; 1834094.A5764_08980; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000092171; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd05195; enoyl_red; 2.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 3.40.50.11460; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 2.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF21089; PKS_DH_N; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 2.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 2.
DR   SMART; SM00829; PKS_ER; 2.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF50129; GroES-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          34..457
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1978..2053
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2071..2495
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          4020..4095
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   COILED          2..32
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   4176 AA;  433992 MW;  893A128547E41C91 CRC64;
     MVDQLQHATE ALRKALVQVE RLKRTNRALL ERSSEPIAIV GMSCRFPGGI DTPEGLWQMV
     ADGRDVISDF PTDRGWDLPG LFDPDPDARH KCYVRTGGFV DGVGDFDPAF FAIAPSEALA
     MDPQHRMLLE LSWEALERAG IDPTGLRGSA TGVFAGLIVQ GYGMLAEEIE GYRLTGMTSS
     VASGRVSYVL GLEGPAVSVD TACSSSLVAL HMAVQSLRTG ECDLALAGGA TVNATPTVFV
     EFSRHRGLAP DGRCKAYAGA ADGVGWSEGG ALLVVERLSD ARRLGHPVLA VVRGSAVNQD
     GASNGLTAPN GPSQQRVVRA ALANAGLSAA DVDVVEGHGT GTTLGDPIEA QALLATYGQD
     RAEPGTPLWL GSIKSNMGHT QAAAGVAGVI KMVQAMRHET LPATLHVDAP SPHVDWSAGS
     VSLLTEPRPW SADGRLRRAG VSSFGISGTN AHVIVEAAPE PQPRDAAPAL PVVPWVISAK
     SASALASQAS RLADHVRAHG DLDIADVAWT LAGRSNFEHR AVVVGGDRDR LLAGLDELAA
     DDLGGSVIRG TAAPAGKNVF VFPGQGSQWL GMGIELLDTA PVFAQQIEAC AEAFAEFVDW
     SLTDVLRGAP GAPGLDRVDV VQPVLFATMV SLAELWKSVG VSPDAVIGHS QGEIAAAYVA
     GALSLRDAAR VVTLRSKLLR SLAHPGGMLS IACSTERARE LLAPYGNRVS IAAVNGPSAV
     VVSGEVAALE ELVGFCADLD LRTRRIDVDY ASHSVEVEAI RGELAEALAG IEPRSSRVAF
     FSTVTGSRLD TAGLDAAYWY RNIRQTVQFD QAVRSACEHG YRTFIEASPH PALIAGIEDT
     FNDCVTGDAE PIVVPTLGRD EGGLERFLTS AAAAFVAGAG VDWRGVVGGA GFVELPTYAF
     ERRRFWLSGE GAGADAAGLG LGISEHALLG AVVELPASGG VVLTGRLSPG AQGWLADHAV
     SGVLVFPGAG FVELAIRAGD EVGCSVVDEL TLQAPLTLPT SGSVAVQVVV GPAEETRRRA
     VSIYSRADAD AGSAWVCHAE GALSSQPVEP GVDLSVWPPA GAVAVDLADG YERLAARGYG
     YGPAFQGLTA AWVRGDEVFA EVRLPDAAGG VGGFGVHPAL LDAAMHAVVM ADSAGQETEV
     LLPFSWQGVS LHAAGAAAVR ARIAPTGRPA GSPAVSIELA DGLGLPVLSV AAMVARSVSE
     RQLRAAVSGS GPDRLFEVVW SAGAKTPTSG GSVPSFEVFE SVAAEGDPVS ATYERTHRAL
     TALQSWLTDR DSGVLVVATR GAAAMVGEDV TDLAGAAVWG LVRSAQTEHP GRIVLVDSDV
     PLDDAAGAAL VTAIVAAGEP QVLVRGGQVY LPRVHGSRGV EGILAPPGDG PWRLGLSSAG
     TFENLRLEPV PNADAPLQPG QVRVAVRAIA ANFRDVMITL GMFTHDALLG GEGAGVVVEV
     GPGVTEFAVG DSVYGFFPDG SGTLVPGDVR LLLPMPSDWS YAEAAAISAV FTTAYMAFVH
     LADVKPGQRV LVHAAAGGVG MAAVQLARHL GLEVFGTASR GKWDTLRAMG LDDDHISDSR
     SLEFEDKFRT ATGGRGFDVV LDSLAGEFVD ASLRLVAPGG VFLEMGKTDI RDPGVVAQEY
     PGVRYRAFDL FEPGRPRMHQ WMLELAELFD AGVLQPLPVT TFDVRRAPAA LRYLSQARHI
     GKVVMTLPGG GLAAGTVLIT GGTGMAGSTL ARHLVAQHGV RNLVLLSRRG RDAVGSAELV
     AELQAAGAQV RVVACDAADR AALAAVLDDI PEQHPLSGVI HAAGVLDDAL VTSLSPERVD
     AVLRAKVDAA WNLHELTRDR DMSAFVMFSS MAGLVGSSGQ GNYAAANSFL DAVAAHRRAH
     GLPAISLAWG LWDQASAMTG GLDAADLARL GRDGILALSS DEAMELFDTA LILDEPFLAP
     ARIDLATLRA NAAAVPPMFT DLVNAPLRRQ VDDSLAAAKS KSALAHRLHG LPEAEQHAVL
     LDLVRSHIAT VLGNTAPEAI DPDKAFQDLG FDSLTAVEMR NRLKAATGLA LSPTLIFDYP
     TPNGLAGYIR GELAGVPQEI AAAPVVQATG DDPIVIVGMA CRYPGGVASP DDLWDMLTEG
     RDVLSEFPTD RGWNLADLYD PDPDVPGTCY TRTGGFVDGV ADFDPAFFGI APTEALAMDP
     QQRMFLELSW EALERAGIEP GALRGSATGV FAGVYTQGYG IGAPPAAEGF RLTGQSSSIA
     SGRISYVLGL EGPAVSVDTA CSSSLVALHM AVQSLRSGEC DLALAGGVTV NATPDIFVEF
     SRMRGLSADG RCKAFAGAAD GTGFSEGGGM LVVERLSDAR RLGHPVLAVV RGSAVNQDGA
     SNGLTAPNGP SQQRVVRAAL ANAGLSAADV DVVEGHGTGT MLGDPIEAQA LLATYGQGRA
     EPLWLGSIKS NMGHTQAAAG VAGVIKMVQA MRHETLPATL HVDEPSPHVD WSAGSVSLLT
     EARPWKPEQA NGHVRRAGVS SFGISGTNAH VIIEAVPSDR VVDRPKLPAV PWVVSAKSAS
     ALASQAARLA DHVRGHGDLD IADVAWTLAG RSNFEHRAVV VGDDRDRLLA GLDGLAAADL
     SGSVIQGTAT AGGKTVFVFP GQGSQSLGMG MGLHAGYPVF AEAFNTVVAE LDRHLLRPLR
     EVMWGHDESL LNTTEFAQPA LFAVEVALFR LLESWGVRPD FVMGHSVGEL TAAHVAGVLS
     LENAAVLVAA RGRFMQALPP GGAMVAVQAT EEEVRPLLDG EVGIAAVNGP ASVVISGAEE
     AVAALADRLR AEGRRIHRLA VSHAFHSPLM EPMIDEFGTV AAGLAIGRPS IPLVSNLTGQ
     LAGDDFASVA YWQRHIREAV RFADSVRFAH SAGVTRFLEV GPSGGLTASI EESLPDTPVV
     TTSALRKDRP EPATLLNVVA QGFVTGMDVN WRAALGQANL VELPTYAFER RRFWLAADGA
     PADAAGLGLQ ASEHALLGAV VELPATGGVV LTGRLSPATQ AWLADHAVGG VVLFPGAGFV
     ELAIRAGDEV GCGVVDELNL AAPLVLPTAG SVAVQVVVGG PDDAGARAVS VFSRAETGSG
     WLLHAEGVLS AGSVEPSAEL SAWPPVGAVP VDVGDGYERL AERGYRYGPA FRGLTSMWRR
     GDEVFAEVAL PADAGVSVAG FGVHPVMLDA ALHAVILASD DGELAEGSVL VPFSWQGVSL
     HAAGASAVRA RIVRTGPAGS PAVSIELADG LGLPVLSVSS MVARPVSDRQ LLAAVSNAGP
     DRLFEVIWSA QPSAAVQPVL VQRWGTTESA DVEPGAMLFE SAPVMGDVVS GVRAATRSVL
     EVLQSWLARD GSATLVVSTH GAAALPGEDV TDLAGAAVWG LVRSAQTEHP GRIVLADTDV
     PLDDDAIAAA LAVGEPQVVL RDGTAYTARV HGSRAVSAVL VPPGEGPWRL GMSSHGTFEN
     LRLERIPNAD APLGPGQVRV ALSAIAANFR DVMIALGLYP DPDAVMGVEA SGVVIECATE
     DGRFAVGDRV MGLFPEGTGT VACTDERLLV KVPVGWSHTA AATTSVVFAT AFYALVDLAR
     VKPGQRVLVH AAAGGVGMAA VQLARHFGLE VFATASHGKW NTLRAMGFDE DHIADSRSCE
     FEDKFRAVTG GHGFDVVLDS LAGEFVDASL RLVAPGGVFL EMGKTDIRDA DAIAAEYPGV
     RYRAFDLFEA GPDRIQQMLA ELAGLFGEEV LRPLPVTTFD VRRAPAALRY LSQARHVGKV
     VMTLPTAPGG WLGAGTVLIT GGTGMAGSAL ARHVVARHGV RNLLLLSRRG PDAPGAAELT
     AELTAAGAAV QVVACDAADR EALAKVVADI PVQRPLSAVI QAAGALDDAV VMSLTPERMD
     AVLRSKVNAA WNLHEVTRDL DVSAFVMFSS MAGLVGSSGQ GNYAAANSFL DGLAVHRRAH
     GLPAVSVAWG LWDQASSMTG GLATVDFARF ARDGIVAMSS DEALQLLDTA MIVDEPFMLP
     AHIDFAALRV KFDGGTLPPM FVDLINAPTR RQVDDSLAAA KSKSALLQRL EGLAEDEQQA
     ILLDLVRSNI ATVLGSGSPE AIDPDRAFQE LGFDSLTAVE MRNRLKSATG LPLSPTLIFD
     YPNSAALAGY MHRELVGASD QLAPAAAPGE AEIQRVVGSI PVKRLRQAGV LELLLALANE
     GEGGRQAAVP AAGSEKDIAD MDLDDLVNSA LLDDDE
//
DBGET integrated database retrieval system