ID A0A1A2G9H0_9MYCO Unreviewed; 382 AA.
AC A0A1A2G9H0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:OBG26071.1};
GN ORFNames=A5764_05870 {ECO:0000313|EMBL:OBG26071.1};
OS Mycobacterium sp. 852002-51057_SCH5723018.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834094 {ECO:0000313|EMBL:OBG26071.1, ECO:0000313|Proteomes:UP000092171};
RN [1] {ECO:0000313|Proteomes:UP000092171}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=852002-51057_SCH5723018 {ECO:0000313|Proteomes:UP000092171};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Mehaffy C., Tameris M.,
RA Hatherill M., Hanekom W., Mahomed H., Mcshane H.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBG26071.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LZIR01000063; OBG26071.1; -; Genomic_DNA.
DR RefSeq; WP_067113847.1; NZ_LZIR01000063.1.
DR AlphaFoldDB; A0A1A2G9H0; -.
DR STRING; 1834094.A5764_05870; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000092171; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:OBG26071.1}.
FT DOMAIN 5..251
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 259..380
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 338
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 368
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 382 AA; 39603 MW; 0AE9DC4E703EC243 CRC64;
MAEAVIVEAV RSPIGKRNGG LSGVHPADLS AQVLNGLADK AGIDPGIVDD VIWGCVMQAG
EQALDIGRTA LLAAGWPETV PGVTVDRQCG SSQQSIHFAA AGVVAGHYDV VVAGGVESMS
RTPMGASLAN GGRPYPQAFI DRYEGQIPNQ GLGAEMIAEQ WGLDRTALDE FSLASHEKAA
AAQDSGAFDD QIVGIKDQDG NPVLKDEGIR RGTPMEKMAS LKPAFKEDGV IHAGNSSQIS
DGSAAILFMS AEKAKSLGLK PIAKVHTATL AGANPVIMLT APIPATQKAL KRSGLSIDDI
GAYEVNEAFA PVPLAWLKDI GADEKKLNPN GGAIALGHPL GGSGARLMTT LLYHMRDKGI
RYGLQTMCEG GGQANATIVE LL
//
