ID A0A1A2H7D9_9MYCO Unreviewed; 231 AA.
AC A0A1A2H7D9; A0A1A3D6S2; A0A1W9Y0U1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:OBI94704.1};
DE SubName: Full=Iron-dependent transcriptional regulator IdeR {ECO:0000313|EMBL:MCV7381512.1};
GN Name=ideR {ECO:0000313|EMBL:MCV7381512.1};
GN ORFNames=A5660_11380 {ECO:0000313|EMBL:OBI94704.1}, H7K38_23055
GN {ECO:0000313|EMBL:MCV7381512.1};
OS Mycobacterium alsense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=324058 {ECO:0000313|EMBL:OBI94704.1, ECO:0000313|Proteomes:UP000092229};
RN [1] {ECO:0000313|EMBL:OBI94704.1, ECO:0000313|Proteomes:UP000092229}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1137317.9 {ECO:0000313|EMBL:OBI94704.1,
RC ECO:0000313|Proteomes:UP000092229};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MCV7381512.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCUG 55640 {ECO:0000313|EMBL:MCV7381512.1};
RA Pettersson B.M.F., Behra P.R.K., Ramesh M., Das S., Dasgupta S.,
RA Kirsebom L.A.;
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:MCV7381512.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCUG 55640 {ECO:0000313|EMBL:MCV7381512.1};
RX PubMed=36243697;
RA Behra P.R.K., Pettersson B.M.F., Ramesh M., Das S., Dasgupta S.,
RA Kirsebom L.A.;
RT "Comparative genome analysis of mycobacteria focusing on tRNA and non-
RT coding RNA.";
RL BMC Genomics 23:0-0(2022).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC {ECO:0000256|ARBA:ARBA00007871}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI94704.1}.
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DR EMBL; JACKVH010000020; MCV7381512.1; -; Genomic_DNA.
DR EMBL; LZKT01000174; OBI94704.1; -; Genomic_DNA.
DR RefSeq; WP_067325549.1; NZ_MVHD01000031.1.
DR STRING; 324058.BST11_17230; -.
DR OrthoDB; 3208141at2; -.
DR Proteomes; UP000092229; Unassembled WGS sequence.
DR Proteomes; UP001141650; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR Gene3D; 2.30.30.90; -; 1.
DR Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR007167; Fe-transptr_FeoA.
DR InterPro; IPR001367; Fe_dep_repressor.
DR InterPro; IPR036421; Fe_dep_repressor_sf.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR022687; HTH_DTXR.
DR InterPro; IPR022689; Iron_dep_repressor.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR PANTHER; PTHR33238:SF10; IRON-DEPENDENT REPRESSOR IDER; 1.
DR Pfam; PF02742; Fe_dep_repr_C; 1.
DR Pfam; PF01325; Fe_dep_repress; 1.
DR Pfam; PF04023; FeoA; 1.
DR SMART; SM00899; FeoA; 1.
DR SMART; SM00529; HTH_DTXR; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50944; HTH_DTXR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..65
FT /note="HTH dtxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50944"
SQ SEQUENCE 231 AA; 25340 MW; CAD66E98A2F15406 CRC64;
MNELVDTTEM YLRTIYDLEE EGVTPLRARI AERLEQSGPT VSQTVSRMER DGLLHVAGDR
HLELTDKGRA LAIAVMRKHR LAERLLVDVI GVPWEEVHAE ACRWEHVMSE DVERRLVKVL
NHPTTSPFGN PIPGLLDLGV GPESGADDVN LVRLTELPAG SPVAVVVRQL TEHVQGDIDL
ITRLKDAGVV PNARVTVETS PVGGGVTILI PGHENVTLPH EMAHAVKVEK V
//
