ID A0A1A2LD99_9MYCO Unreviewed; 381 AA.
AC A0A1A2LD99;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:OBG88788.1};
GN ORFNames=A5699_16030 {ECO:0000313|EMBL:OBG88788.1};
OS Mycobacterium sp. E802.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834152 {ECO:0000313|EMBL:OBG88788.1, ECO:0000313|Proteomes:UP000092062};
RN [1] {ECO:0000313|EMBL:OBG88788.1, ECO:0000313|Proteomes:UP000092062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E802 {ECO:0000313|EMBL:OBG88788.1,
RC ECO:0000313|Proteomes:UP000092062};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBG88788.1}.
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DR EMBL; LZJD01000023; OBG88788.1; -; Genomic_DNA.
DR RefSeq; WP_067765462.1; NZ_LZJD01000023.1.
DR AlphaFoldDB; A0A1A2LD99; -.
DR Proteomes; UP000092062; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:OBG88788.1}.
FT DOMAIN 5..250
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 258..379
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 337
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 367
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 381 AA; 39291 MW; 1D788D9316250FD1 CRC64;
MPEAVIVEAV RSPIGKRNGA LAGIHPAELS AQVLNGLVQR AGVDPGIVDD VIWGCVMQAG
DQALDIARTA LLGAGWPDTV AGVTIDRQCG SSQQSVHFAA ASVAAGHCDV VVAGGVEAMS
RVPMGASLAG GGNPFFAGFM GRYGTHPNQG IGAEMIAEKW GFNRTMVDEF SLNSHEKASA
AQDSGAFDDQ IVPIVDQDGH AVTTDEGVRR GTTIEKMGSL KPAFKEDGVI HAGNSSQISD
GAAALLVMSA EKAAALGLKP MARVHTATLA GVDPIIMLTG PIPATEKALK KAGLRPEAIG
VFEVNEAFAP VPMAWLKDIG ADEKRLNPNG GAIALGHPLG GSGARLMTTM LHHMRDNGIR
YGLQTMCEGG GQANATIVEL I
//
