ID   A0A1A2U3X5_MYCSC        Unreviewed;       560 AA.
AC   A0A1A2U3X5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=3-ketosteroid-delta-1-dehydrogenase {ECO:0000313|EMBL:OBH83225.1};
GN   ORFNames=A5679_05100 {ECO:0000313|EMBL:OBH83225.1};
OS   Mycobacterium scrofulaceum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1783 {ECO:0000313|EMBL:OBH83225.1, ECO:0000313|Proteomes:UP000092207};
RN   [1] {ECO:0000313|EMBL:OBH83225.1, ECO:0000313|Proteomes:UP000092207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2838 {ECO:0000313|EMBL:OBH83225.1,
RC   ECO:0000313|Proteomes:UP000092207};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBH83225.1}.
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DR   EMBL; LZJY01000467; OBH83225.1; -; Genomic_DNA.
DR   RefSeq; WP_067312021.1; NZ_LZJY01000467.1.
DR   AlphaFoldDB; A0A1A2U3X5; -.
DR   Proteomes; UP000092207; Unassembled WGS sequence.
DR   GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          7..541
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
SQ   SEQUENCE   560 AA;  60380 MW;  1AA24D2A34FB5BCB CRC64;
     MTAQELDVVV VGSGGAGMVA ALTAAHRGLS TVVIEKAAHF GGSTARSGGG VWIPNNEVLK
     RDGVRDNPEA ARTYLHGIVG NVVEPERIDT YLERGPEMLS FVLKHTPLKM CWVPRYSDYY
     PEAPGGRAEG RSIEPKPFDA RKLGADMPGL EPAYGKVPLN VVVMQQDYVR LNQLKRHPRG
     VLRSLKVGAR TMWAKATGKN LVGMGRALIG PLRIGLQQAG VPVLLNTALT DLYVEDGVVR
     GVYVRDTGAS ESSEPRLIRA RRGVILASGG FEHNEQMRVK YQRAPITTEW TVGAKANTGD
     GIVAAEKLGA ALELMEDAWW GPTVPLVGAP WFALSERNSP GSIIVNMSGK RFMNESMPYV
     EACHHMYGGE FGQGPGPGEN IPAWLVFDQQ YRDRYIFAGL QPGQRIPRKW LESGVIIQAD
     TLEELAQKAG LPVADFTATV ARFNGFARSG VDEDFHRGES AYDRYYGDPT NKPNPNLGEL
     AHAPYYAAKM VPGDLGTKGG VRTDIHGRAL RDDGSIIEGL YAAGNVSAPV MGHTYPGPGG
     TIGPAMTFGY LAALHIAGAR
//