ID A0A1A2VUV8_MYCSC Unreviewed; 1101 AA.
AC A0A1A2VUV8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:OBI04363.1};
GN ORFNames=A5679_15405 {ECO:0000313|EMBL:OBI04363.1};
OS Mycobacterium scrofulaceum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1783 {ECO:0000313|EMBL:OBI04363.1, ECO:0000313|Proteomes:UP000092207};
RN [1] {ECO:0000313|EMBL:OBI04363.1, ECO:0000313|Proteomes:UP000092207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2838 {ECO:0000313|EMBL:OBI04363.1,
RC ECO:0000313|Proteomes:UP000092207};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI04363.1}.
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DR EMBL; LZJY01000180; OBI04363.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A2VUV8; -.
DR Proteomes; UP000092207; Unassembled WGS sequence.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 31..139
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1037..1101
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
SQ SEQUENCE 1101 AA; 119652 MW; 859D8CA315C0D6DA CRC64;
MLATMSQHAE MPSLNWNELG VSELLPTGTV TLLLADVEGS TRLWETQPEQ MTAALARLNK
TVNDAVDAHA GVRPLEQGEG DSFVAAFSRA SDAVACALAV QRAPLAPIRL RIGIHTGEIQ
LRDDANYAGP TINRTARLRD LAHGGQTVLS GATESMVVDR LPDGVWLADL GSYPLRDLPR
PERVVQLCHP DLVNEFPPLR VGNPVAAHNL PTQLTSFIGR EAEIEQLRHI VADNRMVTLT
GAGGVGKTRL AIEITSDLSD RFPDGQWYVD LAPITIPAVV PVAVARALGL PDQQGRSTTE
LLVRFFGRRN VLLLLDNCEH LIDACVALTE ELLKACPQLT ILATSREPLG VPGEFGWRVP
SLSLADEAIE LFADRARRSR PDFVVGEDNR APVEEICWRL DGMPLAIELA AARVRALSLQ
QILDSLHDRF RLLTGGARTA VRRQQTLRAS VDWSHALLTE PERMLFRRLA AFAGGFDLHA
AQAVGAGSEV ESYQLLDQLS LLVDKSLVVA EETGAGMRYR LLETVRQYAQ EKLGESGESD
EVRTRHRDYY TAKAAELASE GHSSDEQFLR WAETEVENLR AAFTWCRENS DLETGLRLIV
SLRPLWLRGG RVLEGIAGLD AILSQVGDSD ITPAVWAEAV VQRQALQGWL GNPIDLGPAQ
RALAIARELD DPALITRALI GCGMSTVYSP EVAQYYYAEA IQLARAADDH WSLCQIYSHQ
ATVGAFAGEP IAGRAAAEAG RDLADKLGDR FYSRNCRTWL TIAVMMQSHL AEANDLAGSL
VEEAEAAGEV VMKIYGHTVR SVVLSRQGRA AAARSAAESA LAAADAVGGA AEDTVYAMLA
DAALTAGDAG EALRLCETAW QRTSPSREVF TRSVNPIAEA ALACGHLEVA RRWADENVAI
VPGYQQMVAL TARAYIAMAQ GEPGQAERDT HDALAVAARV QGYLRVPDAL ECLACLAVDA
GNHPHAARLL GAADGMRRRT GEVRRPMYES GYRAVLMKAR EALPDSDFDT NWAEGAALST
EQAIAYAQRG RGERKRPASG WESLTPMEHD VVRLVREGLG NKEIGARLFV SPRTVQTHLT
HVYAKLGISS RVQLIKDQHC T
//
