ID A0A1A2YTU6_9MYCO Unreviewed; 210 AA.
AC A0A1A2YTU6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
GN ORFNames=A5707_10630 {ECO:0000313|EMBL:OBI40351.1};
OS Mycobacterium kyorinense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=487514 {ECO:0000313|EMBL:OBI40351.1, ECO:0000313|Proteomes:UP000093592};
RN [1] {ECO:0000313|Proteomes:UP000093592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E861 {ECO:0000313|Proteomes:UP000093592};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001008};
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI40351.1}.
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DR EMBL; LZKJ01000200; OBI40351.1; -; Genomic_DNA.
DR RefSeq; WP_065016642.1; NZ_LZKJ01000200.1.
DR AlphaFoldDB; A0A1A2YTU6; -.
DR OrthoDB; 9774907at2; -.
DR Proteomes; UP000093592; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF4; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:OBI40351.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:OBI40351.1}.
FT DOMAIN 5..203
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 210 AA; 22338 MW; 08D3ACC6C048A400 CRC64;
MLIAIEGVDG AGKRTLSGGL RTAFEAAGKS VATCAFPRYG QSVAADVAHE ALHGQHGDLA
SSVYAMAMLF ALDRAGAAGQ IRELCGEHDV VILDRYVASN AAYSAARLNQ HADGDVAAWV
QQIEFQRLQL PVPDWQVLLG VSAELAGERA RLRARQEVGR ARDAYERDAA LQQRTGAVYA
GLAAAQWGGR WLVVDADVDP EELAATLVGR
//
