ID A0A1A2ZEC3_9MYCO Unreviewed; 1279 AA.
AC A0A1A2ZEC3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=A5707_19345 {ECO:0000313|EMBL:OBI47441.1};
OS Mycobacterium kyorinense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=487514 {ECO:0000313|EMBL:OBI47441.1, ECO:0000313|Proteomes:UP000093592};
RN [1] {ECO:0000313|Proteomes:UP000093592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E861 {ECO:0000313|Proteomes:UP000093592};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI47441.1}.
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DR EMBL; LZKJ01000087; OBI47441.1; -; Genomic_DNA.
DR RefSeq; WP_065014202.1; NZ_LZKJ01000087.1.
DR AlphaFoldDB; A0A1A2ZEC3; -.
DR Proteomes; UP000093592; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17574; REC_OmpR; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 2.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 2.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 2.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OBI47441.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 347..561
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 601..716
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 649
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1279 AA; 136109 MW; CA78BF57BD47B1CF CRC64;
MTEPRTLPPD LAAAVELGGE MGHRFAEFDW AAHPLGQPGQ WPAEFRAATA TALTSRFPIV
LWLGVEDLSL VYNDAYKPIL SDKHPAALGR PGRSVWWDIW DSIGPMLAGV IGSGEATWSN
DLMLPIMTAG RRHERYFTFT YSPLIDDGGS TSGIFCAVAE TTERVLGERR LHVLNSVASA
VMEAQTIDDA VNAAVEVCTD QPADLPFVAA YVGGSDATLR GATPAVLAVL PHTLTELTDR
IPEPGSRDSV EVFDGVASAI PGLDEALGSG CPDQALVLPL GEGPTAGALV VAVNPRCPLN
EQYRGFCQLL ADQLSTGIAA AVSYEQERQR AEALAELDRA KTAFLTNVSH EFRTPLTLLL
GPLDDALSEA GSDALLTHRL RTAQRNARRL LRQVDSLLDF SRIEAGRAAA NLVCSDVGVL
TAHIASSFAE LCQRAGLDLV VDCRPVLADI DPAMWETVML NLLSNAVKYT LDGSITVAVR
SESGQCRISI RDTGVGIAAE DLERLGERFF RAGSAQGRSV EGTGIGLSLV RGLVELHHGS
MEITSEPDRG TTVSVRLPGS VGRTPVEHSP VDLLDNPYVV EAGQWLAPPL AAAPGDDGRQ
LVLIADDNAD MRAHLERVLS VHWRTVLVTD GEAALRTTRE LHPDAVVTDV MMPKLDGFDF
VAAIREDPEL AATPIVMLSA RAGAEAVSEG YAGGADDYLV KPFRSQDLVD RVAARLSAAG
REIADRQRRE AELQLASGLA QLDAALQAAE SVPKILEALL ESPLGSGDAT SIAIGVLDAE
QNTVRFDYAG VVPAELRDRY HVAALDTPLV PIEVIKTGKP IVVSDTFDLE QRYQHVVRET
VDIVRACVSQ PLRGRDGRVI GSLGLLWPTP RELGSDELDV FARTAELTQS ALDRIRLAQR
EHRIAVDFQE HLLDLDRGST AAVVAAVYQP AGEAMRVGGD WYLVAPLERP GQIAISVGDV
VGHGLPAATV MSRLRAAVAA TALNDADPAA VLNALDRYAA SVSGARCATV SYAVIDTEAA
TVDDGPASIS YSCAGHPYPL LVAPGESPAF LESGRRPPVA AWDTDRGPDT ATRELTPGSL
VLLYTDGLIE RPGETLDQGF ARLRDAAASC ADLPVGETCT ALVEKMRPPG GYTDDVVVLA
LRPSHIAAHS FAIVLPAAAA HIADARHRLR RWLAGIGADP QREADILLAT GEAVTNAIEH
GSNGDPNSTV SVEAFLRGDT VTATISDTGR WSGDSSASMR GRQRGRGLTL INGLADHVDT
TRTAQGTRLT LRFDHLVAS
//
