ID A0A1A2ZF69_9MYCO Unreviewed; 930 AA.
AC A0A1A2ZF69;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=A5705_13620 {ECO:0000313|EMBL:OBI49289.1};
OS Mycobacterium sp. E787.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834150 {ECO:0000313|EMBL:OBI49289.1, ECO:0000313|Proteomes:UP000092152};
RN [1] {ECO:0000313|Proteomes:UP000092152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E787 {ECO:0000313|Proteomes:UP000092152};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI49289.1}.
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DR EMBL; LZKL01000110; OBI49289.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1A2ZF69; -.
DR Proteomes; UP000092152; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 7.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR45333:SF1; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN; 1.
DR PANTHER; PTHR45333; MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF13676; TIR_2; 1.
DR Pfam; PF00400; WD40; 13.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50104; TIR; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 10.
DR PROSITE; PS50082; WD_REPEATS_2; 13.
DR PROSITE; PS50294; WD_REPEATS_REGION; 12.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 206..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..182
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REPEAT 295..338
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 340..381
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 383..424
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 426..467
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 469..510
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 511..552
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 554..588
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 635..676
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 678..719
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 721..762
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 764..805
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 807..848
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 850..881
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 930 AA; 98313 MW; 4DBE489CCA9FE2DD CRC64;
MMSDAMQALP PVVGRVVPEY DAFLSYTHRD RLVASGIQKG LHRVGRRLGQ LRALRVFRDD
TNLEVSPDLW GKITEAMDRA RFLVMVLSPA AAQSYWVDRE VGYWLQTRGR TQLLLVLAGG
RLRWDGVGQR FDPGLSDAAP PVLTRPGVLP TEPFFVDVSA DAPWDPQAGP LRDKITALAA
PIHGKPKDQL AGDDLREQRR FRRLRAAAIA GMVALTVVSL VAALIAVVQR QEAIRQRNQA
IAERLTAEAQ SMLAGARAGG DIRAFGELLA ARKAAPLGQS ALLHAVGQRS TTLKVVDTGA
EVPGVAFSPD GHKIATAGGG PDGTVQLWDV DTGRPIGDPL KGHTNKVTSV AFSPDGHRLA
SGSWDDTVRL WDADTGQPIG DPLKGHQDFV EDVAFSPDGH LLASAGWDRT VRLWDADSGR
PVGAPLGGYT SFVHSVAFSP DGHLLATGSY DGTLALWDTD TARLMGALQA GQKGGLVTVV
FSPDGRRMAS ASADRTVRQW DTGTGQPIGS PLNHPGAVFG VAYSPDGHRL ATAGSDATVR
LWDADTGHAL GAALTGHTDA AISVAYSPDG HRIASGGRDH SLRVWNLDEI LAGYAYELEG
VTFSPDGHRV ASAGAGPRGA VWVWNADTGQ PVKTLTGHTD SVLGVAFSPD GHRLASAGAD
QTVRLWDADT GEPIGAPLTG HTGIVSSVAF SPDGHRLASA SWDHTVRLWD ADTGQPIGAP
LDGHTDAVWS VAFSPDGHRL ASGGADDTVR LWDVSSGKPI GDPLAGHSNT VDSVAFSPDG
RVLASASWDH TIRLWNAGTH RQIGAALKGH TNTVTSVAFS PDGHRLASGG ADLTVRLWNA
ETGQELTEPF VGHTNLVSSV AYSPDGQRLA SASMDRTIRL WPAQATPKML CDKVNSNMSR
KQWRDWISAD IGYSTLCPGL PVTADGSGGA
//
