ID A0A1A2ZL57_9MYCO Unreviewed; 1043 AA.
AC A0A1A2ZL57;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=A5705_09120 {ECO:0000313|EMBL:OBI51324.1};
OS Mycobacterium sp. E787.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834150 {ECO:0000313|EMBL:OBI51324.1, ECO:0000313|Proteomes:UP000092152};
RN [1] {ECO:0000313|Proteomes:UP000092152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E787 {ECO:0000313|Proteomes:UP000092152};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI51324.1}.
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DR EMBL; LZKL01000085; OBI51324.1; -; Genomic_DNA.
DR RefSeq; WP_068278722.1; NZ_LZKL01000085.1.
DR AlphaFoldDB; A0A1A2ZL57; -.
DR Proteomes; UP000092152; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 4..331
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 317..611
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1043 AA; 108755 MW; A83E03F53E79D7B5 CRC64;
MSYTWDDGAR AVLAPGLRGR VRVLGGPGTG KSSLLVDAAV ARIGVGVEPE SVLLLTGSGR
IGVRARSALT RALLRSRSTG PGRAAVREPL VRTVHGYAYA VLRRAAERAG DAPPRLVTSA
EQDAIIRELL AGDLEDGTRS ASGWPAHLRP ALATAGFATE VRNLLARCAE RGVDPQELER
LGRRCGRPEW TAAGRFARQY EQVMLLRAAV GTAAPQATTP ALGAAELVGA ALEAFAVDPK
LLAAERARVR VLLIDDAQQL DPQAAGLVRA LAAGTETTLI AGDPNQAVFG FRGGEGSGLL
ADDSPSVTLT VSHRCAPAVA RAVSGVAGRL PGGSAGRRID GTGPEEGSVA VRLAASAHAE
AAMIADALRR AHLVDGVPWS QMAVIVRSVP RAGARLPRAL AAAGVPIAAP SSSGSLSDEP
AARALLTVLA ATAGGLDGDL ALALLTGPIG RVDPVSLRQL RRTLQRANPD RAPGDFGGLL
VEALHADAPL PGPQSRALRR VRAVLDAAAR CDRDGQDPRY TLWAAWQRSG LQRRWLSAAE
RGGPAGAQAA KDLEAVTALF DITDHYVART PGASLRGLVE HVAALQVPGA NTEPDCRAEQ
VRVLSAHAAL GHEWDFVVIA GLQDGLWPNT VPRGGVLHTQ RLLDALDGVS GDASVRAPLL
AEERRLLVAA LGRARRRLLV TAVDGDAGGA DAEAALPSAF FSEIAQWADC GDPVAAQPVS
APRVLSTAAV VGRLRSVVCA PAGAVDDAVR RCAATQLARL AQAGVPGADP AGWHGLLPVS
TGAPLRASGE PVTLTPSTLQ TLNDCPLRWL AERHGGSSPR ELRSTLGSVL HALIAQPGKT
ESELLAELDR AWRHLPFEAR WHSANELARH RAMVRAFLEW RAQTRGELTE VGVEVGVDGT
LGTPREDGGE IRLRGRVDRL ERDAAGRLVI VDVKTGKTPV SKDDAQQHAQ LAAYQLAVAE
GLIAGGDEPG GARLVYVGKA GAGGAIVREQ DPLTAAARDE WRDLVRHAAD ATAGPQFVAR
RNDGCAHCPI RPCCPAHADG TTP
//
