ID A0A1A2ZMY6_9MYCO Unreviewed; 553 AA.
AC A0A1A2ZMY6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase {ECO:0000313|EMBL:OBI51058.1};
GN ORFNames=A5705_09545 {ECO:0000313|EMBL:OBI51058.1};
OS Mycobacterium sp. E787.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834150 {ECO:0000313|EMBL:OBI51058.1, ECO:0000313|Proteomes:UP000092152};
RN [1] {ECO:0000313|Proteomes:UP000092152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E787 {ECO:0000313|Proteomes:UP000092152};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI51058.1}.
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DR EMBL; LZKL01000089; OBI51058.1; -; Genomic_DNA.
DR RefSeq; WP_067881424.1; NZ_LZKL01000089.1.
DR AlphaFoldDB; A0A1A2ZMY6; -.
DR Proteomes; UP000092152; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OBI51058.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OBI51058.1}.
FT DOMAIN 13..239
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 297..527
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 57557 MW; 3FD80AF4816386AC CRC64;
MTTRGRKPRP GHITFVGSGP GDPGLLTTRA ATVLANAALV FTDPDVPEPV LALIGRDLPP
VSGPAPAGPE AKAEGNPDGD AGQAGPAVIT EGPDIRPALG EPAEVAKTLV AEARTGADVV
RLVAGDPLTL DAVITEVNAV ARSHLHIEIV PGLAATSAVP TYAGLPLGSS HTVADVRGDV
DFDALAAAPG PLILQATASH VADAARALIE HELAEATPCV VTAQGTTCQQ RSVETTLAGL
TDPAVLGGND PAGPMTGPLV VTIGKTVASR AKLNWWESRA LYGWTVLVPR TKDQAGEMSE
RLTSYGALPI EVPTIAVEPP RSPAQMERAV KGLVDGRFQW VVFTSTNAVR AVWEKFGEFG
LDARAFSGVK IACVGESTAD RVRAFGISPE LVPAGEQSSL GLLDDFPPYD SVFDPVNRVL
LPRADIATET LAEGLRERGW EIEDVTAYRT VRAAPPPAAT REMIKTGGFD AVCFTSSSTV
RNLVGIAGKP HARTIIACIG PKTAETAAEF GLRVDVQPDT AAVGPLVDAL AEHAARLRAE
GALPPPRKKS RRR
//
