ID   A0A1A2ZU80_9MYCO        Unreviewed;      1394 AA.
AC   A0A1A2ZU80;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:OBI53032.1};
GN   ORFNames=A5705_03645 {ECO:0000313|EMBL:OBI53032.1};
OS   Mycobacterium sp. E787.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1834150 {ECO:0000313|EMBL:OBI53032.1, ECO:0000313|Proteomes:UP000092152};
RN   [1] {ECO:0000313|Proteomes:UP000092152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E787 {ECO:0000313|Proteomes:UP000092152};
RA   Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA   Him V., Kerleguer A., Cheng S.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBI53032.1}.
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DR   EMBL; LZKL01000055; OBI53032.1; -; Genomic_DNA.
DR   RefSeq; WP_068277498.1; NZ_LZKL01000055.1.
DR   Proteomes; UP000092152; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10786; GH38N_AMII_like; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
FT   DOMAIN          394..465
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1394 AA;  149142 MW;  32FEFC7719619C2D CRC64;
     MQVISAGSTE LFVGPPDAPL QLARVDVAGC AEPTPIRIDG DGLSGEAVAP AGAGVVEVPV
     TVDGAAVGQR RAARVRAGSV TAPFEFTVAE PGWTMFMVSH FHYDPVWWNT QGAYTSEWAE
     DPPGRQTNGF ELVHAHLEMA RREPEYKFVL AEVDYLKPYW DTHPEDRADL RRFLAEGRVE
     VMGGTYNEPN TNLTGPETTI RNLVHGSGFQ RRVLGADPAT AWQLDVFGHD PQFPGMAADA
     GLTSSSWARG PHHQWGPGGG IERMQFCSEF EWIAPSGRGL LTHYMPAHYG AGWGMDESAS
     LAEAEAATFA LFDRLKKVAL TRNVLLPVGT DYTPPNKWVT AIHRDWAARY TWPRFVCALP
     REFFAAVRAE LAQRGREPSP QTRDMNPIYT GKDVSYIDTK QANRAAENAV LAGERFAVFA
     ALMTGAEYPQ PAFAKAWVQL AYGAHHDAIT GSESDQVYLD LLTGWRDAWE LGRAARDNSL
     ARLSALVVGQ VLGDLVVWNP LAHRRSDVVT ARLDPSPAAG VRVLDPDGVE VPAHVEHDGR
     SVTWLARDVP SLGWRAYRLA PADHANGWES MAGTAIGNEH YRLEVDPRRG GGVVSLVREG
     RQLIAAGRVG NELALYEEYP AHPQQGEGPW HLLPKGPVVC SSEVPARVRA YRGPLGQRLV
     VRGRVGGLLR YTQTLTLWHG VDRLDCRTAI DEFTGADTLL RLRWPCPVPG AMPVSEVGDA
     VVGRGFALLH DGDRSVDTAQ HPWTLDNPAY GWFGLSSAVR VRVGDDVRAV SVAEVVTPAE
     SVSGPLAREL MVALVRAGVT ATCSGADRPR YGCLDVDSNL PDVRIALGGP ARNSFAKAVL
     AQADPQYTAE LDRQLAATGR ARVWVPAEAP LAAAWVPGAD LRSPRALPVL VVDGDPGLPD
     DGLAAAIASV VDDLGDFEIV VAQDPRRAPP GMQRFESHTV ALLNRGVPSF AVDTDGTLHT
     ALMRSCTGWP SGTWIDDPRR TAPDGSNFQL QHWTHAFEYA LVSGDGDWRQ AEIPSRAAQF
     ADPLLAVVPG GARGGLAPCG SLLHVEPANT VQLGALKAAG NPLTTGSARP VDPGAVALRL
     VETTGNGVRV DLGSGPGTVR GLQFADLLEN PGRDTTSIDL HGYQIATVLA RLEIPSFSTA
     SERSARLAPD AEAAQPLYAR YWLHNRGPAP LGGLPAVAHL HPRRVTAVPG GQVALRLTAA
     SDCSDAALAG AVTLVCPDGW SAAPAELPFR LRAGEHREAD LVLSVPPRAR PGLYPVRAQL
     GLTGDDVSAA WRQVVEDVCV VEVGDCAEAE LLHLVDGPVD VELAAGGTAR LAVTVGTHAR
     ADLALEGHLI SPWGTWEWIG PAALGAVLPA GGAVELGFDV APPPWLDPGR WWALVRVGCA
     GRLLYSPAVR VTVT
//