ID A0A1A3BCG7_9MYCO Unreviewed; 416 AA.
AC A0A1A3BCG7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Beta-ketoacyl-[acyl-carrier-protein] synthase II {ECO:0000313|EMBL:OBI72023.1};
GN ORFNames=A5663_08620 {ECO:0000313|EMBL:OBI72023.1};
OS Mycobacterium sp. E740.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834149 {ECO:0000313|EMBL:OBI72023.1, ECO:0000313|Proteomes:UP000092151};
RN [1] {ECO:0000313|Proteomes:UP000092151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E740 {ECO:0000313|Proteomes:UP000092151};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI72023.1}.
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DR EMBL; LZKP01000215; OBI72023.1; -; Genomic_DNA.
DR RefSeq; WP_068153637.1; NZ_LZKP01000215.1.
DR AlphaFoldDB; A0A1A3BCG7; -.
DR STRING; 1834149.A5663_08620; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000092151; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Reference proteome {ECO:0000313|Proteomes:UP000092151};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 10..415
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 416 AA; 43634 MW; 312E30F41D6C0FA5 CRC64;
MAALRTGDAF PDVVVTAFVS STSLSTDAEQ TWQLLQQGRS GIRPLDKWFV RELDSPVRIG
GAILEDFDEQ LSRVERRRTS YMQKMSTILS RRLWEAAGTP EIDTRRLAVS VGLALGSTEE
IPLQHDLWRK KGLRAVSPLA VQMYMPNGPA AAVGLDRQAK AGIFSPVMAD ASGAAAIAQA
WQHVVLGEAD AVICGGVETQ IEAVPVAAFS LQALLSTNND DPAGACRPFD KDRDGMVFGE
GGALMLVETE QHALARGAEP LARLLGAAVT SDGYDVVRTD PDGIRAGDAV ARAIELAGLA
PTDIGHINAH ATGTVDGDLA EACAIRRALG GHNPAVFAPK AALGHSLGSA GAVEAVLTVQ
ALRDGVVPPT LNLEDLDPGV DLDVVTGSPR RGDYRYAVSN SFGLGGNNVA LVFGAY
//
