ID A0A1A3BDN4_9MYCO Unreviewed; 409 AA.
AC A0A1A3BDN4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=A5663_08590 {ECO:0000313|EMBL:OBI72017.1};
OS Mycobacterium sp. E740.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834149 {ECO:0000313|EMBL:OBI72017.1, ECO:0000313|Proteomes:UP000092151};
RN [1] {ECO:0000313|Proteomes:UP000092151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E740 {ECO:0000313|Proteomes:UP000092151};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI72017.1}.
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DR EMBL; LZKP01000215; OBI72017.1; -; Genomic_DNA.
DR RefSeq; WP_068153631.1; NZ_LZKP01000215.1.
DR AlphaFoldDB; A0A1A3BDN4; -.
DR STRING; 1834149.A5663_08590; -.
DR OrthoDB; 9802808at2; -.
DR Proteomes; UP000092151; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000092151};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 238..397
FT /note="DNA topoisomerase type IIA subunit B"
FT /evidence="ECO:0000259|Pfam:PF00204"
SQ SEQUENCE 409 AA; 45619 MW; 981163EFF91E5E11 CRC64;
MKQFSSGWPI CGKCCEVAYF PWLGGAHRCD VTSRDDWPDY DFFEWEDDSF ESRPFDDFRY
EDGLHRLLWD VIAHSAEVAA SAVSVTLRAD GGVEVSHDGR DPNLDGAIAA LQDNFLSELA
CRTAFPDLAA AYVEEPSERN SLPARLDIEI HRDGFIWFQR YDCGVARLVE CRGATTKTGV
TVRCWPESLV CEMTDGDAGA ALKRLQRMAF LREGLTIDVV DDRRTRPARS RTFCYPGGLV
DYCRFLTRIS MPLHDNVIQL SGRRRGFAVE IAMRWTTGYS PTIQVFDTFS GSPRPSAHEE
AIAHAVTATV AGPVKQHVAD RIPLPAAVPD LTTRDIAEGL TAVVNVRHRA SPPEDERPSP
EVVSIIYTLC HRHLAGWLDA NPRAADLIAD KAIAGHHYAR MPRRSFCRG
//
