ID A0A1A3BWY2_9MYCO Unreviewed; 961 AA.
AC A0A1A3BWY2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Na+/H+ antiporter subunit A {ECO:0000313|EMBL:OBI78878.1};
GN ORFNames=A5663_00070 {ECO:0000313|EMBL:OBI78878.1};
OS Mycobacterium sp. E740.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834149 {ECO:0000313|EMBL:OBI78878.1, ECO:0000313|Proteomes:UP000092151};
RN [1] {ECO:0000313|Proteomes:UP000092151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E740 {ECO:0000313|Proteomes:UP000092151};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI78878.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LZKP01000112; OBI78878.1; -; Genomic_DNA.
DR RefSeq; WP_068147930.1; NZ_LZKP01000112.1.
DR AlphaFoldDB; A0A1A3BWY2; -.
DR STRING; 1834149.A5663_00070; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000092151; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092151};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 72..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 647..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..936
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..102
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 127..398
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 606..670
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 685..764
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 813..935
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 961 AA; 102019 MW; ED845978825198D9 CRC64;
MLAVLLAHAV AAALAPLLVF RWGRAAFYPL ALVPLFSLVW VVLNWPARGR ARSVDIPWVP
NLSMDITLRF DALAAIMSVL VLGIGALVLL YCADYFHHHD GRTENRLPSF AAELVAFSGA
MFGLVTSDNM LLLYVFWEIT TVLSFLLVGH YAERVTSRRA ATQALLVTTF GGLAMLVGII
VLGNLTGSYL LSEVIASRPA GAAVSVAVVL ILIGALSKSA IVPLHFWLPG AMAAPTPVSA
YLHAAAMVKA GVYLIARMTP GFADVAPWRP MVISLGMLTM LLAGWRAVRE YDLKLILAFG
TVSQLGLITI MVGASGSDMM LGGLAMLVAH ALFKASLFMV VGIIDHATGT RDIRRLAWLG
DRSRPLLVIA IGASASMAAL PPFFGFVAKE ADFETVLHSP YLGAASPYVL AGIVLGAVFT
TIYSLRFLFG AFGRKRQSQP SRRVAEMRRP EFSFLVAPGI LSAAGLLFGI WPVGVGDVLE
DYSDTVPGGE DYHLALWHGL NLPLLLSALV IATGVAAFLG RERLRRMRTV REPLGNADHI
YDAVVRRLDL WSVALTAATQ RGSIPATQSV ILSTLVLVPT LALVLGARDR PDFALWGSPL
QVVVGLIILA AAIGALVMRN RLAAVLLVGV TGYGCGVIFA LHGAPDLALT QFLVETLTLV
IFVLVLRTLP AEADRARIKR HRWPRAALAL AVGATVTTLT VYAMSARSGV PIAALIPDAA
YYRGHGANAV NVLLVDIRAW DTMGEVMVLL VAATGVASMV FRHRRFGAAP RVSDAGQPDI
GRLPATVSTS PAAGDVTWLR GSELRDPRHR SLILEVATRL IFPLIMVLSA YFFFAGHNTP
GGGFAGGLTA GLALVLRYLA GGRYELGETL PLDAGKILGA GLCLSAGTAV ASLLVGAPAL
SSALIEVNVP VLGTVKFVTA LCFDLGVYLI VVGLVLDVLR SLGARIDVEL GQEHKTAVAS
R
//
