ID A0A1A3BZ05_9MYCO Unreviewed; 762 AA.
AC A0A1A3BZ05;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=A5663_18030 {ECO:0000313|EMBL:OBI80110.1};
OS Mycobacterium sp. E740.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834149 {ECO:0000313|EMBL:OBI80110.1, ECO:0000313|Proteomes:UP000092151};
RN [1] {ECO:0000313|Proteomes:UP000092151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E740 {ECO:0000313|Proteomes:UP000092151};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Sam S., Sreng N.,
RA Him V., Kerleguer A., Cheng S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBI80110.1}.
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DR EMBL; LZKP01000091; OBI80110.1; -; Genomic_DNA.
DR RefSeq; WP_068146855.1; NZ_LZKP01000091.1.
DR AlphaFoldDB; A0A1A3BZ05; -.
DR STRING; 1834149.A5663_18030; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000092151; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04863; MtLigD_Pol_like; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033649; MtLigD_Pol-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OBI80110.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000092151};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 546..668
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 733..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 84955 MW; 154230C5B587C946 CRC64;
MDRFGRVKLT NPDKVLYPAT GTTKAQMFDY YVGIAEAMIP HIAGRAVTRK RWPNGVDEPS
FFEKQLASSA PEWLDRASVT HRSGTTTYPL IDTAEGLAWI AQQASLEVHV PQWRFITTDD
GPPTPGPATR IVFDLDPGEG VTFRQLCEVA HEVRDLISDI GLTTYPLTSG SKGLHLYVPL
EEPISSQGAS VLARRVAQQL EKTMPKRVTA TMTKSLRAGK VFLDWSQNNG AKTTIAPYSL
RGREHPTVAA PRTWEEIGDP KLRHLRFDEV LERVHEMGDL LAPLDEAVPV PDRLTTYRSM
RDAAKTPEPV PSKPPTTGDN DKFVIQEHHA RRLHYDLRLE RDGVLVSWAV PKNLPDTPSV
NHLAVHTEDH PLEYLTFHGE IPKGEYGGGK MIIWDTGTYE AEKFNDVPPD STKEGGEVII
NLRGAKVDGR YALIQTNGKN WLAHRMKEQN RPHAGDLAPM LSTEGSVAHL KGRQWAFDGK
FDGYRVIIDA DHGRLTVRSR RGRDVTGEFP QFEALAADLA DHHVILDGEA VALDESNVPS
FSEMQNRARS TRVEFWAFDV LHLDGRSLLR AKYSDRRRIL ETLAEGGGLI MQELLPGDGP
EALEHARKKG WEGVVAKKRD STYQPGRRSS SWIKDKLWNT QEVVIGGWRV GEGGRSSGIG
SLMLGIPDPK NPAGGLQFVG RVGTGFTDKA LAELKKTLKP LETTDSPFNE RLPRADAKGV
TFVRPELVGE VRYSERTSDD RLRQPSWRGL RPDKEPADVS WE
//
