ID A0A1A3HRZ1_9MYCO Unreviewed; 680 AA.
AC A0A1A3HRZ1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=A9W95_23090 {ECO:0000313|EMBL:OBJ50920.1};
OS Mycobacterium sp. 1423905.2.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1856859 {ECO:0000313|EMBL:OBJ50920.1, ECO:0000313|Proteomes:UP000092291};
RN [1] {ECO:0000313|Proteomes:UP000092291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1423905.2 {ECO:0000313|Proteomes:UP000092291};
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E., Garcia-Basteiro A.,
RA Lopez-Varela E., Palencia S.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBJ50920.1}.
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DR EMBL; LZLE01000259; OBJ50920.1; -; Genomic_DNA.
DR RefSeq; WP_067415126.1; NZ_LZLE01000259.1.
DR AlphaFoldDB; A0A1A3HRZ1; -.
DR Proteomes; UP000092291; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00065; GAF; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 503..631
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 680 AA; 72859 MW; 96F1A099D1EA7E01 CRC64;
MVIGVGSYRG SALRTANWLM HLALPMLALW LLLAQPKVDL AWDNRVAHFV LVLSASAVSV
GLGVSIGRAA RARDDARLWL VSLVFVTTAG FFGVHALVTP GVLVDTSDAD FMLPTRMGLV
LSGLIALASA ITFNPARNAR LWQLRRGLSM LIGALMASCA VVVYLGLLDR LPDQDRVEGV
EQDAALVGCV LFALAALAYF PVYRRRPAVV LMSVLTSFVL LAEASVALAL GMSWHASWWL
WHLLMTTAFC FIAYSARVRF HQEGSARGLF DALATRQTIA ELRRDYAAAL EAMVDLLQRR
ERGERVPPGA VTTRLADRFG LTEQQVAVLK RGAEALGAER ERVRKLGRLV AVGRESSVIQ
DEDVLLDAVV SAINDAFPDD QVRLGLVHAG ELRFEDDPAG EIAGSGSFTT DSDQQADAMQ
LPLMVKGQVA GVITVRRPGG TFTDADVALL RSFATQSSIA LENARLYRHL DGLFRSYMSP
AVATALLADP DQAGLGGALT EVTVLMADLR GFTAFTEAHS PEQVVTMLNT YYGAIVPVIL
DAGGTVTQFV GDAMMAIWGA PVRQPDHALL AARAGLALHE VVEQAAAGHP DWPRFRVGIN
TGPAVVGNIG AAEMRNFTAI GDTTNLAARL QSLARAGQVV VGPGTVAALG PAARVSEHGW
VRVKGKRDPV RVCVLHEVHE
//
