ID A0A1A3KFI8_MYCAS Unreviewed; 73 AA.
AC A0A1A3KFI8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Translation initiation factor IF-1 {ECO:0000256|HAMAP-Rule:MF_00075};
GN Name=infA {ECO:0000256|HAMAP-Rule:MF_00075};
GN ORFNames=A5634_20395 {ECO:0000313|EMBL:OBK28539.1}, A5635_19415
GN {ECO:0000313|EMBL:OBK23459.1}, A5636_06090
GN {ECO:0000313|EMBL:OBK15243.1}, A5640_20670
GN {ECO:0000313|EMBL:OBJ82766.1}, A9X01_10570
GN {ECO:0000313|EMBL:OBI91337.1};
OS Mycobacterium asiaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1790 {ECO:0000313|EMBL:OBJ82766.1, ECO:0000313|Proteomes:UP000093925};
RN [1] {ECO:0000313|Proteomes:UP000093629, ECO:0000313|Proteomes:UP000093795}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1081914.2 {ECO:0000313|EMBL:OBI91337.1,
RC ECO:0000313|Proteomes:UP000093795}, 1165133.8
RC {ECO:0000313|EMBL:OBK28539.1, ECO:0000313|Proteomes:UP000093928},
RC 1245139.5 {ECO:0000313|EMBL:OBK15243.1,
RC ECO:0000313|Proteomes:UP000093629}, 1245335.1
RC {ECO:0000313|EMBL:OBK23459.1, ECO:0000313|Proteomes:UP000093819}, and
RC 1276495.2 {ECO:0000313|EMBL:OBJ82766.1,
RC ECO:0000313|Proteomes:UP000093925};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit
CC to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps
CC modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).
CC Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are
CC released leaving the mature 70S translation initiation complex.
CC {ECO:0000256|HAMAP-Rule:MF_00075}.
CC -!- SUBUNIT: Component of the 30S ribosomal translation pre-initiation
CC complex which assembles on the 30S ribosome in the order IF-2 and IF-3,
CC IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at
CC any time during PIC assembly. {ECO:0000256|HAMAP-Rule:MF_00075}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00075}.
CC -!- SIMILARITY: Belongs to the IF-1 family. {ECO:0000256|ARBA:ARBA00010939,
CC ECO:0000256|HAMAP-Rule:MF_00075}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBJ82766.1}.
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DR EMBL; LZKQ01000028; OBI91337.1; -; Genomic_DNA.
DR EMBL; LZLM01000104; OBJ82766.1; -; Genomic_DNA.
DR EMBL; LZLQ01000088; OBK15243.1; -; Genomic_DNA.
DR EMBL; LZLR01000077; OBK23459.1; -; Genomic_DNA.
DR EMBL; LZLS01000075; OBK28539.1; -; Genomic_DNA.
DR RefSeq; WP_003418601.1; NZ_LZMH01000069.1.
DR AlphaFoldDB; A0A1A3KFI8; -.
DR SMR; A0A1A3KFI8; -.
DR STRING; 1790.A5645_19725; -.
DR GeneID; 83874299; -.
DR eggNOG; COG0361; Bacteria.
DR OrthoDB; 9803250at2; -.
DR Proteomes; UP000093629; Unassembled WGS sequence.
DR Proteomes; UP000093795; Unassembled WGS sequence.
DR Proteomes; UP000093819; Unassembled WGS sequence.
DR Proteomes; UP000093925; Unassembled WGS sequence.
DR Proteomes; UP000093928; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043022; F:ribosome binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd04451; S1_IF1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00075; IF_1; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR004368; TIF_IF1.
DR NCBIfam; TIGR00008; infA; 1.
DR PANTHER; PTHR33370; TRANSLATION INITIATION FACTOR IF-1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR33370:SF1; TRANSLATION INITIATION FACTOR IF-1, CHLOROPLASTIC; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00075};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_00075};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00075}; Reference proteome {ECO:0000313|Proteomes:UP000093629};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_00075};
KW rRNA-binding {ECO:0000256|HAMAP-Rule:MF_00075}.
FT DOMAIN 1..73
FT /note="S1-like"
FT /evidence="ECO:0000259|PROSITE:PS50832"
SQ SEQUENCE 73 AA; 8489 MW; 70CEB2A79E874448 CRC64;
MAKKDGAIEV EGRVVEPLPN AMFRIELENG HKVLAHISGK MRQHYIRILP EDRVVVELSP
YDLSRGRIVY RYK
//
