ID A0A1A3MJT1_MYCAS Unreviewed; 560 AA.
AC A0A1A3MJT1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=3-ketosteroid-delta-1-dehydrogenase {ECO:0000313|EMBL:OBK10213.1};
GN ORFNames=A5636_15950 {ECO:0000313|EMBL:OBK10213.1};
OS Mycobacterium asiaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1790 {ECO:0000313|EMBL:OBK10213.1, ECO:0000313|Proteomes:UP000093629};
RN [1] {ECO:0000313|EMBL:OBK10213.1, ECO:0000313|Proteomes:UP000093629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245139.5 {ECO:0000313|EMBL:OBK10213.1,
RC ECO:0000313|Proteomes:UP000093629};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK10213.1}.
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DR EMBL; LZLQ01000150; OBK10213.1; -; Genomic_DNA.
DR RefSeq; WP_065161238.1; NZ_LZLQ01000150.1.
DR AlphaFoldDB; A0A1A3MJT1; -.
DR OrthoDB; 9813348at2; -.
DR Proteomes; UP000093629; Unassembled WGS sequence.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000093629}.
FT DOMAIN 7..541
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 560 AA; 60265 MW; 2B28C6103069540D CRC64;
MTAQEYDVVV VGSGGAGMVA ALTAAHRGLS TVVIEKAPHF GGSTARSGGG VWIPNNEVLR
RDGVKDTPDA ARTYLHGIVG DVVEPERIDT YLQRGPEMLS FVLKHTPLKM CWVPRYSDYY
PEAPGGRAEG RSIEPKPFDA RKLGADEAGL EPAYGKVPLN VVVMQQDYVR LNMLKRHPRG
VLRSLKVGAR TMWAKSTGKN LVGMGRALIG PLRIGLQQAG VPVVLNTALT DLYVEDGVVR
GVYVRDAAGA EAADSRLIRA RRGVILASGG FEHNEQMRVK YQRAPITTEW TVGAQANTGD
GILAGEKLGA ALDLMEDAWW GPTVPLVGAP WFALSERNSP GSIIVNMSGK RFMNESMPYV
EACHHMYGGQ YGQGPGPGEN IPAWLVFDQQ YRDRYIFAGL QPGQRIPRKW MESGVIIQAD
SLAELAAKAG LPVDEFTETV ARFNAFARAG VDQDFHRGES AYDKYYGDPT NKPNPNLGEL
AHAPYYAAKM VPGDLGTKGG IRTDVHGRAL RDDGSIIEGL YAAGNVSAPV MGHTYPGPGG
TIGPAMTFGY LAALHIAGVN
//
