ID A0A1A3MPM2_MYCAS Unreviewed; 1077 AA.
AC A0A1A3MPM2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=A5636_16050 {ECO:0000313|EMBL:OBK10137.1};
OS Mycobacterium asiaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1790 {ECO:0000313|EMBL:OBK10137.1, ECO:0000313|Proteomes:UP000093629};
RN [1] {ECO:0000313|EMBL:OBK10137.1, ECO:0000313|Proteomes:UP000093629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245139.5 {ECO:0000313|EMBL:OBK10137.1,
RC ECO:0000313|Proteomes:UP000093629};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK10137.1}.
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DR EMBL; LZLQ01000151; OBK10137.1; -; Genomic_DNA.
DR RefSeq; WP_065161240.1; NZ_LZLQ01000151.1.
DR AlphaFoldDB; A0A1A3MPM2; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000093629; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000093629}.
FT DOMAIN 17..347
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 348..659
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1077 AA; 115328 MW; 9940814DC33AD93D CRC64;
MSPRYSPAEL ADALGVFRPT DEQAAVIAAP PGPLVVIAGA GAGKTETMAA RVVWLIANGY
ADPSQVLGLT FTRKASGQLM RRVRSRLARL AGVGVETGST PTVSTYHAFA GALLREYGLL
LPVEPDTRLV TETEVWQLAF DVVTGYRGDL DTDKTPAMVT SLVLRLWGQL AEHLVDTDQL
RHTHVELERL VHTLPAGPHQ RERGPNQWLL RMLATQTERS ELVPLLDALR DRMRAEKVMD
FGMQMASAAR LAATFPQVGA DLRSRYRVVL LDEYQDTGHS QRVALSSLFG GGVDDGLALT
AVGDPIQSIY GWRGASATNL PRFTTDFPLA DGSPAPTLEL RTSWRNPPRT LHLANAISAE
ARRRSVAVRP LRSRPDAAPG TLRCALLPDI QIERDWIADQ LQVCYRDAQR DGAAPPTAAV
LVRRNADAAP IADALRARGI PAEVVGLAGL LSIPEVADLV AMLRLVADPA AGASAMRVLS
GPRWRLGGRD IAALWRRARE LNGPVRPAEP LSAQAIAIAA DADTACLAEA ISDPGPAEGY
SAAGYARIKA LAGELATLRG HLGYALPDLV AEVRRVLGLD CEVRATAGGE WSGAEHLDAF
ADEVAGYAER AGGCSNNASV EGLLAYLDVA AQVEGGLAPA QPAVARDRVQ VLTVHAAKGL
EWQVVAVAHL SGGTFPSTAS RSSWLTDPGE LPPLLRGDRA AAGSLGVPVL DTSAVTNRKQ
LSDKIFEHRT ELDQRRVDEE RRLLYVGVTR AEDTLLVSGH HWGATGIKPR GPSEFLREIK
DIVDRSAAAG DPCGTVAHWA PTPADGERNP LRDNVVEAIW PADPLVRRSD VERGARLVSQ
AVPADANQPD VEGWIADVDA LLAERARATR PPDRTLPPQL SVSGLVELAR DPEAATQRLI
HRLPTRPDPH ALLGNAFHAW VQRFYGAELL FDLGDLPGAA DSDVGDSTEL AALQATFADS
PWAARTPIAV EVPFEMPIGD TVVRGRIDAV FADSDGGVTV VDWKTGEPPR GAQARRQAAI
QLAVYRLAWA ALHGCPESKV RTAFYYVRSG LTILPDELAG ADELAALLEH SGRPRTA
//