ID A0A1A3MZX3_MYCAS Unreviewed; 981 AA.
AC A0A1A3MZX3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=A5636_06780 {ECO:0000313|EMBL:OBK15081.1};
OS Mycobacterium asiaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1790 {ECO:0000313|EMBL:OBK15081.1, ECO:0000313|Proteomes:UP000093629};
RN [1] {ECO:0000313|EMBL:OBK15081.1, ECO:0000313|Proteomes:UP000093629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245139.5 {ECO:0000313|EMBL:OBK15081.1,
RC ECO:0000313|Proteomes:UP000093629};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK15081.1}.
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DR EMBL; LZLQ01000090; OBK15081.1; -; Genomic_DNA.
DR RefSeq; WP_065159240.1; NZ_LZLQ01000090.1.
DR AlphaFoldDB; A0A1A3MZX3; -.
DR OrthoDB; 4747874at2; -.
DR Proteomes; UP000093629; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000093629};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 869..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..388
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 616..943
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 960..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 514..541
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 981 AA; 107292 MW; 80CD03AA8A83098A CRC64;
MSETAEAPPR VEQPLIPPFL PRMIHRLALP IVLIWLGIVF VTNTVAPQLE VVAKTHSVSM
SPTDAASFQS MMHIGKTFKE FDSDNSAMIL IEGNKPLGAE AHRYYDEIVK RVEQDTKHVQ
HVQDFWSDPL TAAGSQSHDQ KAAYVQVYLS GNMGGGMADE SSLALRKMVD SVPAPPGIKA
YVTGAGPLFA DQSHSGEKGI MLVTLITILV IVVMLLIVYR SITTVLVMLA MVFIELAAAR
GVVATLGNYG IMGLSTFANN MLVLMAIAAG TDYAIFVVGR YQEARGIGET REQAFYTMFH
STAHVVLGSG LTIAGAMYCL SFCRLPYFSS LGVPCAVGML VAVLAALTLG PALLTVASFF
KLMDPKRKLQ TRGWRRLGTA VVRWPAPVLA VTIAIALVGL LALPGYKTDY DNRHYLPAST
PANVGYAAAD RHFDQARLNP ELLMIETDHD LRNSADFLVL DKVAKAVFHI PGIGRVQTIT
RPLGTPLDHS TLGFQMGAQA AGRIQTQHYQ DEQAKNLLTQ ADELRKTMAT LHEQMQVTQE
LSNTTHETTV LTKETVQITE ALRDDIATFD DFFRPIRSYF YWEKHCYDIP ICWALRSIFN
ALDGIDQVAQ NILSLSANLD KLDQIQPKLV ALIPPQIESQ QRNLDTIMSN YATTAGLNAQ
ARAQADNATA QGDAFDRAKN DDTFYLPPEA FQSPDFARGL KQFISPDGHA VRLIISHEGD
PATPEGIKNI EPIKQAVHEA IKGTPWEGAK VYLGGTAATY KDMHDGSNID LLIAGISAAT
LIFIIMLVIT RSVVAAFVIV GTVLLSLGAS FGLSVLLWQY ILGIKLHWMV LAMAIILLLA
VGSDYNLLLI SRLKEEIRAG LKTGTIRAMA GSGSVVTSAG LVFAATMATF MFSPLRVMAQ
VGTTIALGLL FDTLIVRSFM TPSLATLFGR WFWWPTRVRT RPSSQMLRPF GPRPAVRALL
REDDDRSDPP NANRVATQPH Y
//
