ID A0A1A3PJ71_9MYCO Unreviewed; 717 AA.
AC A0A1A3PJ71;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OBK33795.1};
GN ORFNames=A5658_11795 {ECO:0000313|EMBL:OBK33795.1};
OS Mycobacterium sp. 1245111.1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834073 {ECO:0000313|EMBL:OBK33795.1, ECO:0000313|Proteomes:UP000092232};
RN [1] {ECO:0000313|EMBL:OBK33795.1, ECO:0000313|Proteomes:UP000092232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245111.1 {ECO:0000313|EMBL:OBK33795.1,
RC ECO:0000313|Proteomes:UP000092232};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK33795.1}.
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DR EMBL; LZLV01000136; OBK33795.1; -; Genomic_DNA.
DR RefSeq; WP_067339726.1; NZ_LZLV01000136.1.
DR AlphaFoldDB; A0A1A3PJ71; -.
DR STRING; 1834073.A5658_11795; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000092232; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 325..503
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 506..605
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 717 AA; 76486 MW; 12BBF3857F2849E5 CRC64;
MAENTIHWDK DADGIVTLTL DDPTGSANVM NEHYSESMHN AVERLVAEKD SITGVVITSA
KKTFFAGGDL KGMIKLGPEN AGEAFDTVEG VKRDLRALET LGKPVVAAIN GAALGGGLEI
ALACHHRIAA DVKGLVVGLP EVTLGLLPGG GGVTRTVRMF GIQNAFMNIL SQGTRFKADK
AKEIGLVDEI VGSVEELVPA AKAWIKGVKD NQDSYTQPWD KKGYKMPGGT PSSPALAAVL
PSFPALLKKQ LKGAPMPAPR AILDAAVEGA QVDFDTASRI ESRYFTQLVT GQVAKNMIQA
FFLDLQHING GGSRPDGIAP VKINKIGVLG AGMMGAGIAY VSAKAGYDVV LKDVSIEAAQ
KGKAYSEKLE AKAIERGKTT EEKSKALLDR ITPAADPEAL KGVDFVVEAV FENQDLKHKV
FQEIEDIVEP NALLGSNTST LPITGLASGV KRQEDFIGIH FFSPVDKMPL VEIIKGEKTS
DEALARVFDY TLAIGKTPIV VNDSRGFFTS RVIGTFVNEA LAMLGEGVEP ASIEHAGSQA
GYPAPPLQLS DELNLELMHK IAVASRKGIE DAGGTYEPHP AEAVVEKMIE LERPSRLKGA
GFYEYVDGKR TRLWPGLRET FKSGSTELPL QDMIDRMLFA EALETQKCLD EGVLTSTADA
NIGSIMGIGF PPYTGGSAQF IVGYEGAHGI GKEAFVARAR ELAARYGDRF LPPPSLT
//
