ID A0A1A3PSX8_9MYCO Unreviewed; 391 AA.
AC A0A1A3PSX8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Mycofactocin radical SAM maturase {ECO:0000313|EMBL:OBK37288.1};
GN ORFNames=A5658_04200 {ECO:0000313|EMBL:OBK37288.1};
OS Mycobacterium sp. 1245111.1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834073 {ECO:0000313|EMBL:OBK37288.1, ECO:0000313|Proteomes:UP000092232};
RN [1] {ECO:0000313|EMBL:OBK37288.1, ECO:0000313|Proteomes:UP000092232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245111.1 {ECO:0000313|EMBL:OBK37288.1,
RC ECO:0000313|Proteomes:UP000092232};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK37288.1}.
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DR EMBL; LZLV01000089; OBK37288.1; -; Genomic_DNA.
DR RefSeq; WP_067334827.1; NZ_LZLV01000089.1.
DR AlphaFoldDB; A0A1A3PSX8; -.
DR STRING; 1834073.A5658_04200; -.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000092232; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21123; SPASM_MftC-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR023913; MftC.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR03962; mycofact_rSAM; 1.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 2.
DR SFLD; SFLDF00316; C-terminal_tyrosine_decarboxyl; 1.
DR SFLD; SFLDG01216; thioether_bond_formation_requi; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 16..226
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 352..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 42225 MW; 1E4DC0BB20953241 CRC64;
MTSTVPRLIE QFEHGLDAPI CLTWELTYAC NLACVHCLSS SGKRDPRELS TQQCKDIIDE
LERMQVFYVN IGGGEPTVRP DFWELVDYAT AHHVGVKFST NGVRITPEVA ARLAASDYVD
VQISLDGATA EINDAVRGPG SFAMAIRALE NLAAAGFQDA KISVVVTRHN VAQLDEFASL
ASRYGATLRI TRLRPSGRGA DVWDDLHPTA DQQVQLYDWL VAKGERVLTG DSFFHLSGLG
EPGALAGLNM CGAGRVVCLI DPIGDVYACP FAIHDRFLAG NVVSDGGFDK VWKDAPLFRE
LREPQSAGAC GSCGHYDSCR GGCMAAKFFT GLPLDGPDPE CVQGYGVPAL ALERDKPRPA
GDHSHRGRRK SGPVPLTLTM PPQKLCNESP V
//
