ID A0A1A3PUD2_9MYCO Unreviewed; 361 AA.
AC A0A1A3PUD2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Bifunctional RNase H/acid phosphatase {ECO:0000313|EMBL:OBK37778.1};
GN ORFNames=A5658_03860 {ECO:0000313|EMBL:OBK37778.1};
OS Mycobacterium sp. 1245111.1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834073 {ECO:0000313|EMBL:OBK37778.1, ECO:0000313|Proteomes:UP000092232};
RN [1] {ECO:0000313|EMBL:OBK37778.1, ECO:0000313|Proteomes:UP000092232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245111.1 {ECO:0000313|EMBL:OBK37778.1,
RC ECO:0000313|Proteomes:UP000092232};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK37778.1}.
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DR EMBL; LZLV01000074; OBK37778.1; -; Genomic_DNA.
DR RefSeq; WP_067334607.1; NZ_LZLV01000074.1.
DR AlphaFoldDB; A0A1A3PUD2; -.
DR STRING; 1834073.A5658_03860; -.
DR OrthoDB; 5296884at2; -.
DR Proteomes; UP000092232; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
FT DOMAIN 1..139
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT ACT_SITE 168
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 242
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 218
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 361 AA; 38641 MW; BB01446934EE6293 CRC64;
MKVVVEADGG SRGNPGPAGY GSVVWSADRS IVLAEAKQAI GQATNNVAEY RGLIAGLEEA
ANLHATEVAV SMDSKLVIEQ MSGRWKVKHP DLAELNAQAR SLASRFDRVS YTWIPRAENS
HADRLANEAM DAAAEMSAQT DVPAAETAAA PGWTGARGAA TRLLLLRHGQ TELSVQRRYS
GRGNPPLTTL GRQQADAAAR YVGSRGGVAA VISSPLQRCH DTATASAKRL GLDVVVDDDL
IETDFGGWEG LTFSEASEQD PELHRRWLRD TSTEPPGGES FDDVDKRVSR ARDRIVAEYG
GSTVLVVSHV TPIKMLLREA LDAGPGILYR LHLDLASLSI AEFYPDGASS VRLVNQTGYL
G
//
