ID A0A1A3Q063_9MYCO Unreviewed; 247 AA.
AC A0A1A3Q063;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] reductase MabA {ECO:0000256|ARBA:ARBA00040781};
DE AltName: Full=3-ketoacyl-acyl carrier protein reductase {ECO:0000256|ARBA:ARBA00033040};
DE AltName: Full=Beta-Ketoacyl-acyl carrier protein reductase {ECO:0000256|ARBA:ARBA00029743, ECO:0000256|ARBA:ARBA00032683};
GN ORFNames=A5658_25605 {ECO:0000313|EMBL:OBK38984.1};
OS Mycobacterium sp. 1245111.1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834073 {ECO:0000313|EMBL:OBK38984.1, ECO:0000313|Proteomes:UP000092232};
RN [1] {ECO:0000313|EMBL:OBK38984.1, ECO:0000313|Proteomes:UP000092232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245111.1 {ECO:0000313|EMBL:OBK38984.1,
RC ECO:0000313|Proteomes:UP000092232};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+)
CC + NADPH; Xref=Rhea:RHEA:17397, Rhea:RHEA-COMP:9916, Rhea:RHEA-
CC COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:78776, ChEBI:CHEBI:78827; EC=1.1.1.100;
CC Evidence={ECO:0000256|ARBA:ARBA00023333};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17399;
CC Evidence={ECO:0000256|ARBA:ARBA00023333};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK38984.1}.
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DR EMBL; LZLV01000047; OBK38984.1; -; Genomic_DNA.
DR RefSeq; WP_067333407.1; NZ_LZLV01000047.1.
DR AlphaFoldDB; A0A1A3Q063; -.
DR STRING; 1834073.A5658_25605; -.
DR OrthoDB; 9804774at2; -.
DR Proteomes; UP000092232; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd05333; BKR_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR NCBIfam; NF040605; mycolic_FabG1; 1.
DR PANTHER; PTHR42879; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE; 1.
DR PANTHER; PTHR42879:SF2; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Secreted {ECO:0000256|ARBA:ARBA00022512}.
SQ SEQUENCE 247 AA; 25850 MW; 2742617294F4B521 CRC64;
MTDVATDGGK PPFVSRSVLV TGGNRGIGLA IAQRLAADGH KVAVTHRGSG APEGLFGVVC
DVTDNDAVDR AFKEVEEHQG PVEVVVSNAG ISKDAFLIRM TEERFEEVIN ANLTGAFRVA
QRASRSMQKK RFGRIIFIGS VSGTWGIGNQ SNYAAAKAGL IGMARSISRE LSKANVTANV
VAPGYIDTEM TRSLDERIQE GALDFIPAKR VGTAAEVAGA VSFLASEDAT YIAGAVIPVD
GGMGMGH
//
