ID A0A1A3Q5I8_9MYCO Unreviewed; 315 AA.
AC A0A1A3Q5I8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dehydrogenase {ECO:0000313|EMBL:OBK41678.1};
GN ORFNames=A5658_17445 {ECO:0000313|EMBL:OBK41678.1};
OS Mycobacterium sp. 1245111.1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1834073 {ECO:0000313|EMBL:OBK41678.1, ECO:0000313|Proteomes:UP000092232};
RN [1] {ECO:0000313|EMBL:OBK41678.1, ECO:0000313|Proteomes:UP000092232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1245111.1 {ECO:0000313|EMBL:OBK41678.1,
RC ECO:0000313|Proteomes:UP000092232};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBK41678.1}.
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DR EMBL; LZLV01000004; OBK41678.1; -; Genomic_DNA.
DR RefSeq; WP_067329741.1; NZ_LZLV01000004.1.
DR AlphaFoldDB; A0A1A3Q5I8; -.
DR STRING; 1834073.A5658_17445; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000092232; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732:SF385; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE A; 1.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857}.
FT DOMAIN 26..288
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 57
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 119
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 86
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 315 AA; 34517 MW; EE863F50F2D42ECD CRC64;
MTSIDDLSRV TFDLNNVTSR MPALGFGTSL SDRSKTRDAV KAAVKVGFRH LDAAERYRNE
ADVGAAIAEL FADGTVRRDE LFVTTKLWNN NHRPERVKPA LQASLNRLGL DTVDLYLVHT
PFAFQPGDDQ DPRDVHGAVI YDDGVTLEET WEAMESLVDE GLTGAIGLSD IDVEGAKRIA
HTARIKPAVV EVESHPYHPQ WEIHQLRETD GIVLLAFASL GHALEPRLLD DPLIVSIAQR
MGKTPAQVLL AWGIQRGSAV LTGSVNPARI RENFDVTAIP ESAIEDINER LETRVRFNSV
VEGGEPGFAE VPAGS
//
