ID A0A1A5NX94_9ACTN Unreviewed; 418 AA.
AC A0A1A5NX94;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Histidine kinase {ECO:0000313|EMBL:OBQ47813.1};
GN ORFNames=A4U61_21295 {ECO:0000313|EMBL:OBQ47813.1};
OS Streptomyces sp. H-KF8.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1727216 {ECO:0000313|EMBL:OBQ47813.1, ECO:0000313|Proteomes:UP000093719};
RN [1] {ECO:0000313|Proteomes:UP000093719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H-KF8 {ECO:0000313|Proteomes:UP000093719};
RA Undabarrena A., Ugalde J.A., Seeger M., Camara B.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBQ47813.1}.
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DR EMBL; LWAB01000011; OBQ47813.1; -; Genomic_DNA.
DR RefSeq; WP_065003129.1; NZ_LWAB01000011.1.
DR AlphaFoldDB; A0A1A5NX94; -.
DR OrthoDB; 5181554at2; -.
DR Proteomes; UP000093719; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR045975; DUF5931.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF65; SENSOR HISTIDINE KINASE COMP; 1.
DR Pfam; PF19354; DUF5931; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OBQ47813.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000093719};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..179
FT /note="DUF5931"
FT /evidence="ECO:0000259|Pfam:PF19354"
FT DOMAIN 190..233
FT /note="Signal transduction histidine kinase subgroup 3
FT dimerisation and phosphoacceptor"
FT /evidence="ECO:0000259|Pfam:PF07730"
FT DOMAIN 309..404
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF02518"
FT REGION 394..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 43369 MW; A9673B28B79312DA CRC64;
MPGRGRVMRM SVEQPMWRAL AGYRVLAMVY AVGLFATAHE EFRRPWLAVA YFALLVVWTP
ATLSRVANAA ACTKRFLAAD LTVALAGILL TPVADAPERI AAGGPTLPSI WTAGAVLAFA
LKGGWRWAAL ASTLVAVANL IERGGPARDT VHNVILVWVA SIAIGYVVEV ARASERTLAR
ALEIEAATRE RERLARDIHD SVLQVLAMVQ RRGAVIGGEA AELGRMAGEQ EVALRTLVSG
GLVPLPGGAE GMAGAAAAPL TAGAAGRAAG GDAAHGPVDL RALLAPYADA LVSLADPGAP
VPLAPASARE LAAAVGAALD NVRTHVGADA RAWILVEDEP DEVIVTVRDD GPGIPEGRLA
QAEGEGRLGV ALSIRGRLRD LGGSAELISV PGQGTEVELK VPKRHSGEQD ARGKAEQR
//
