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Database: UniProt
Entry: A0A1A5P5L8_9ACTN
LinkDB: A0A1A5P5L8_9ACTN
Original site: A0A1A5P5L8_9ACTN 
ID   A0A1A5P5L8_9ACTN        Unreviewed;       393 AA.
AC   A0A1A5P5L8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=AI-2E family transporter {ECO:0000313|EMBL:OBQ50611.1};
GN   ORFNames=A4U61_10545 {ECO:0000313|EMBL:OBQ50611.1};
OS   Streptomyces sp. H-KF8.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1727216 {ECO:0000313|EMBL:OBQ50611.1, ECO:0000313|Proteomes:UP000093719};
RN   [1] {ECO:0000313|Proteomes:UP000093719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H-KF8 {ECO:0000313|Proteomes:UP000093719};
RA   Undabarrena A., Ugalde J.A., Seeger M., Camara B.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC       family. {ECO:0000256|ARBA:ARBA00009773}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBQ50611.1}.
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DR   EMBL; LWAB01000010; OBQ50611.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A5P5L8; -.
DR   OrthoDB; 5242074at2; -.
DR   Proteomes; UP000093719; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002549; AI-2E-like.
DR   PANTHER; PTHR21716; TRANSMEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR21716:SF75; TRANSPORT PROTEIN SLL0063-RELATED; 1.
DR   Pfam; PF01594; AI-2E_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000093719};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        35..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        301..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          346..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   393 AA;  43022 MW;  678C6F6D35FCB412 CRC64;
     MPRWLPRAMV LALVLIALFQ LGSWAFHELT GLLINILIAF FLALAVEPAV SWMAARGVRR
     GLGTFLVFLG VLIVAAGFVT LLGSMLAGQI IKIVEDFPEY LDSVINWINT HFRTELRRVD
     IQEGLLRSDW LRNYVQNSAT GVLDVSTQVL GGLFQLLTIG LFSFYFAADG PRLRRTICSV
     LPPARQAEVL RAWEIAVNKT GGYLYSRGLM ALISGMAHYV LLEILEVPYA PVLAVWVGLV
     SQFIPTIGTY LAGALPMLIA FTVDPWYALW VLIFVVIYQQ FENYVLQPKL TSKTVDIHPA
     VAFGSVVMGT ALLGAVGALI AIPAVATLQA FLGAYVKRYD VTDDPRVHGH RGAGSGNGGP
     GSGERRTLAD RARQFWAHRP GSPGPRSEDT EDT
//
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